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Synonyms: SRY(sex determining region Y) box 4, SRY related HMG box gene 4, SRY box containing gene 4, SOX 4, EVI16, EVI 16, Ecotropic viral integration site 16
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
| Description | Anti-SOX4 Polyclonal Antibody is a Rabbit antibody targeting SOX4. Anti-SOX4 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB. |
| Synonyms | SRY(sex determining region Y) box 4, SRY related HMG box gene 4, SRY box containing gene 4, SOX 4, EVI16, EVI 16, Ecotropic viral integration site 16 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken) |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2ug/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nuclear |
| Tissue Specificity | Testis, brain, and heart. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. |
| Immunogen | KLH conjugated synthetic peptide: human SOX4 |
| Antigen Species | Human |
| Gene Name | SOX4 |
| Gene ID | |
| Protein Name | Transcription factor SOX-4 |
| Uniprot ID | |
| Biology Area | Developmental Families,HMG Box,Neural Stem Cell marker,Neural Signal Transduction,Intracellular |
| Function | The SOX (SRY-box containing gene) gene family encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate. SOX4 shows a high degree of sequence homology with SOX11. Both are expressed in the CNS. SOX4 and SOX11 expression increase together in the developing CNS (with some exceptions: external granule layer of the cerebellum). SOX4 knock-out mice have been shown to die of a heart defect half way through gestation with no observable CNS phenotype, although it has been proposed that SOX11 compensates for the absence of SOX4. |
| Molecular Weight | Theoretical: 52 kDa. Actual: 46 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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