Shopping Cart

Your shopping cart is currently empty

N-Deshydroxyethyl Dasatinib

Name: N-Deshydroxyethyl Dasatinib
Brand: TargetMol
SKU: T18750
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T18750Cas No. 910297-51-7

Alias N-Deshydroxyethyl BMS-354825

N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.

N-Deshydroxyethyl Dasatinib

Copy Product Info

😃Good

Purity: 95.96%

Catalog No. T18750Alias N-Deshydroxyethyl BMS-354825Cas No. 910297-51-7

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$50	-	In Stock
5 mg	$119	-	In Stock
10 mg	$188	-	In Stock
25 mg	$326	-	In Stock
50 mg	$473	-	In Stock
100 mg	$648	-	In Stock
200 mg	$877	-	In Stock
1 mL x 10 mM (in DMSO)	$136	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:95.96%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

N-Deshydroxyethyl Dasatinib AI Summary

N-Deshydroxyethyl Dasatinib shows moderate permeability with a permeability value of 0.0371 × 10⁻⁶ cm/s in a PAMPA assay. It has a ratio of 0.654 for drug concentration in unbound HEK293 cells to media, indicating some cellular activity. The compound exhibits high binding affinity with a Ki value of 3.3 nM for ABL and an even stronger affinity with a Ki value of 0.449 nM for wild-type human SRC. Additionally, it demonstrates enhanced binding affinity relative to the parent compound, with fold changes of 7.2 for ABL and 1.52 for wild-type human SRC. These bioactivities suggest that N-Deshydroxyethyl Dasatinib may be a promising candidate for further development in targeted therapies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.
Synonyms	N-Deshydroxyethyl BMS-354825

Chemical Properties

Molecular Weight	443.95
Formula	C₂₀H₂₂ClN₇OS
Cas No.	910297-51-7
Smiles	N(C1=CC(=NC(C)=N1)N2CCNCC2)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3
Relative Density.	1.403 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49.5 mg/mL (111.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.51 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2525 mL	11.2625 mL	22.5251 mL	112.6253 mL
5 mM	0.4505 mL	2.2525 mL	4.5050 mL	22.5251 mL
10 mM	0.2253 mL	1.1263 mL	2.2525 mL	11.2625 mL
20 mM	0.1126 mL	0.5631 mL	1.1263 mL	5.6313 mL
50 mM	0.0451 mL	0.2253 mL	0.4505 mL	2.2525 mL
100 mM	0.0225 mL	0.1126 mL	0.2253 mL	1.1263 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc