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N-Deshydroxyethyl Dasatinib

🥰Excellent
Catalog No. T18750Cas No. 910297-51-7
Alias N-Deshydroxyethyl BMS-354825

N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.

N-Deshydroxyethyl Dasatinib

N-Deshydroxyethyl Dasatinib

🥰Excellent
Purity: 95.96%
Catalog No. T18750Alias N-Deshydroxyethyl BMS-354825Cas No. 910297-51-7
N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.
Pack SizePriceAvailabilityQuantity
1 mg$50In Stock
5 mg$119In Stock
10 mg$188In Stock
25 mg$326In Stock
50 mg$473In Stock
100 mg$648In Stock
200 mg$877In Stock
1 mL x 10 mM (in DMSO)$136In Stock
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Batch Information

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Purity:95.96%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER. N-Deshydroxyethyl Dasatinib is used in the study of cancer and immune diseases.
SynonymsN-Deshydroxyethyl BMS-354825
Chemical Properties
Molecular Weight443.95
FormulaC20H22ClN7OS
Cas No.910297-51-7
SmilesN(C1=CC(=NC(C)=N1)N2CCNCC2)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3
Relative Density.1.403 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 49.5 mg/mL (111.5 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2525 mL11.2625 mL22.5251 mL112.6253 mL
5 mM0.4505 mL2.2525 mL4.5050 mL22.5251 mL
10 mM0.2253 mL1.1263 mL2.2525 mL11.2625 mL
20 mM0.1126 mL0.5631 mL1.1263 mL5.6313 mL
50 mM0.0451 mL0.2253 mL0.4505 mL2.2525 mL
100 mM0.0225 mL0.1126 mL0.2253 mL1.1263 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N-Deshydroxyethyl DasatinibN-Deshydroxyethyl BMS354825N-Deshydroxyethyl BMS 354825IAPDrugMetaboliteDrug MetaboliteBCR-ABL
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