Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

(S)-CPI203

🥰Excellent
Catalog No. T6026Cas No. 1446144-04-2
Alias CPI203, CPI 203

CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).

(S)-CPI203
Other Forms of (S)-CPI203:
CPI203T2442202591-23-9
In Stock
View details

(S)-CPI203

🥰Excellent
Purity: 99.92%
Catalog No. T6026Alias CPI203, CPI 203Cas No. 1446144-04-2
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$30In StockIn Stock
5 mg$53In StockIn Stock
10 mg$86In StockIn Stock
25 mg$188In StockIn Stock
50 mg$298-In Stock
100 mg$472-In Stock
200 mg$659-In Stock
1 mL x 10 mM (in DMSO)$56In StockIn Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.92%
Contact us for more batch information

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity
Description
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
Targets&IC50
BRD4:37 nM
In vitro
CPI203 inhibits BRD4 in vitro and in cells, while does not affect BRD4 kinase activity in vitro. [1] CPI203 exerts a cytostatic effect in all the 9 MCL cell lines analyzed with GI50 ranging from 0.06 to 0.71 μM, with low cytotoxicity in normal PBMCs from healthy donors. Furthermore, lenalidomide and CPI203, by targeting IRF4 and MYC, efficiently activates the cell death program in MCL cells resistant to bortezomib. [2]
Kinase Assay
BRD4 α-screen assay: The BRD4 α-screen assay is a proximity-based assay using a tetraacteylated H4 peptide and the isolated bromodomain 1 of human BRD4. IC50 values are calculated using a 10-point serial dilution of BET inhibitor.
SynonymsCPI203, CPI 203
Chemical Properties
Molecular Weight399.9
FormulaC19H18ClN5OS
Cas No.1446144-04-2
SmilesCc1nnc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Relative Density.1.51 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (125.03 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5006 mL12.5031 mL25.0063 mL125.0313 mL
5 mM0.5001 mL2.5006 mL5.0013 mL25.0063 mL
10 mM0.2501 mL1.2503 mL2.5006 mL12.5031 mL
20 mM0.1250 mL0.6252 mL1.2503 mL6.2516 mL
50 mM0.0500 mL0.2501 mL0.5001 mL2.5006 mL
100 mM0.0250 mL0.1250 mL0.2501 mL1.2503 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitEpigeneticReaderDomainEpigenetic Reader DomainCPI-203BRD4Apoptosis
Related Tags: buy (S)-CPI203 | purchase (S)-CPI203 | (S)-CPI203 cost | order (S)-CPI203 | (S)-CPI203 chemical structure | (S)-CPI203 in vitro | (S)-CPI203 formula | (S)-CPI203 molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.