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Anti-Human S100B Antibody (6U606)
😃Good
Catalog No. TMAB-07450
Anti-Human S100B Antibody (6U606) is a Mouse antibody targeting Human S100B. Anti-Human S100B Antibody (6U606) can be used in WB,ELISA.
Anti-Human S100B Antibody (6U606)
Anti-Human S100B Antibody (6U606)
😃Good
Catalog No. TMAB-07450
Anti-Human S100B Antibody (6U606) is a Mouse antibody targeting Human S100B. Anti-Human S100B Antibody (6U606) can be used in WB,ELISA.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μg | $470 | 7-10 days | 7-10 days | |
| 200 μg | $1,057 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Human S100B Antibody (6U606) is a Mouse antibody targeting Human S100B. Anti-Human S100B Antibody (6U606) can be used in WB,ELISA. |
| Ig Type | IgG1 |
| Clone | 6U606 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; ELISA: 1:5000-10000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Cytoplasm. Nucleus. |
| Tissue Specificity | Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M PBS (pH7.4). |
| Research Background | S100 beta is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. |
| Immunogen | Recombinant Protein: human S100B protein |
| Antigen Species | Human |
| Gene Name | S100B |
| Gene ID | |
| Protein Name | Protein S100-B |
| Uniprot ID | |
| Function | Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. |
| Molecular Weight | Theoretical: 10 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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