1:1

11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13 μM, respectively. 11β-Hsvd1-in-11 is a compound used as a chemical compound. 11β-HSD1-IN-11 is a hormone involved in regulating various physiological processes, such as metabolism, inflammation, and stress responses. 11β-Hd1-in-11 is a potential compound for the treatment of metabolic disorders, obesity, and certain inflammatory conditions.

[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine is an n-alkylated derivative with analgesic activity.

8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one ,with CAS No. 50892-62-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 8-Chloro-5,10-dihydrodibenzo[b,e][1,4]diazepin-11-one provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

11-Piperazinyldibenz[b,f][1,4]oxazepine, with CAS No. 21636-40-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 11-Piperazinyldibenz[b,f][1,4]oxazepine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor with Kis of 0.06 μM and 4.2 μM for Mcl-1 and Bcl-2, respectively.

ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.

cIAP1 ligand 2, a derivative of LCL161, is an IAP ligand that can be connected to the ABL ligand for protein via a linker, resulting in the formation of SNIPER.

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound comprising an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker, mainly used in the development of SNIPERs for targeted protein degradation[1].

cIAP1 Ligand-Linker Conjugates 11 is a chemical compound that combines an IAP ligand specifically designed for the E3 ubiquitin ligase with a PROTAC linker. This compound, cIAP1 Ligand-Linker Conjugates 11, is useful in the development of SNIPERs[1], allowing for the targeted degradation of proteins.

Compound 12k (THP-1/MV-4-11 against-1) is a 5-substituted thiazolyl urea anticancer agent with significant inhibitory efficacy against THP-1/MV-4-11 cancer cells, demonstrating IC50 values of 29 nM and 98 nM, respectively.

PLK1-IN-11 (Cluster 4, 16953209) is a PLK1 inhibitor with an IC50 of 1 μM. It is applicable in research on various cancers such as pancreatic, ovarian, breast, and non-small cell lung cancer.

USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1). It promotes the activation of the DDR (DNA damage repair) pathway, inducing cell cycle arrest and apoptosis, thereby inhibiting cell viability. USP1-IN-11 increases the sensitivity of cells resistant to Olaparib and shows synergistic effects with Andrographolide in cancer cells with normal BRCA function. In the MDA-MB-436 xenograft model, USP1-IN-11 exhibits a significant dose-dependent antitumor effect.

11-Bromoundecan-1-ol is a PROTAC linker (PROTAC linker) utilized in the synthesis of PROTACs, such as PROTAC GPX4 degrader-4.

CHK1-IN-11 (Compound 1) is an orally active inhibitor of checkpoint kinase 1 (CHK1). It is utilized in research focused on cancers with oncogene amplification.

MMP-11-IN-1 is a new class of phosphinate prodrugs. It is the glycosyl ester of RXP03 and can enhance blood-brain barrier (BBB) permeability.

Gαq/11 protein-IN-1 (compound F33) is a Gαq/11 protein inhibitor with an IC50 value of 9.4 μM, exhibiting anti-tumor activity.

AAK1-IN-11 is an inhibitor of AAK1 (adaptor associated kinase 1) with an IC50 of 2 nM, and it exhibits antiviral activity.

A1B11 is a selective SIRT2 inhibitor.

Syk-IN-11 is a selective Syk inhibitor.

3-Oxo-C16:1-HSL (3oxoC16:1Δ11cis(L)HSL) is an N-acyl-homoserine lactone from Pseudomonas aeruginosa that inhibits the pathogenic strains of Aspergillus vinelandii from causing crown galls on grapes, and can be used in biosensor research.

IDO1-IN-11 is an IDO1 inhibitor with an IC50 value of 0.6 nM.

PARP1-IN-11 (compound 49) is a potent PARP1 inhibitor with an IC50 value of 0.082 μM, demonstrating complete inhibition of PARP1 and substantial inhibition of PARP3, TNKS1, and TNKS2 [1].

Enpp-1-IN-11 (compound 23) is a highly potent inhibitor of Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1), with a Ki value of 45 nM. It demonstrates excellent stability in human and mouse plasma and exhibits low clearance in both human and mouse liver microsomes, holding promise for anticancer research [1].

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65682 and the CAS number is 111974-74-4.