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ELOVL6-IN-4 is a potent and selective long chain fatty acid elongase 6 (ELOVL6) inhibitor that is orally active, with IC50 values of 79 nM for human ELOVL6 and 94 nM for mouse ELOVL6. It demonstrates excellent selectivity over other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 [1].

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $535 | 7-10 days | 7-10 days | |
| 5 mg | $1,366 | 7-10 days | 7-10 days | |
| 10 mg | $2,050 | 7-10 days | 7-10 days |
| Description | ELOVL6-IN-4 is a potent and selective long chain fatty acid elongase 6 (ELOVL6) inhibitor that is orally active, with IC50 values of 79 nM for human ELOVL6 and 94 nM for mouse ELOVL6. It demonstrates excellent selectivity over other human ELOVL subtypes (ELOVL1, -2, -3, and -5) and mouse ELOVL3 [1]. |
| In vitro | ELOVL6-IN-4 (compound 1w) effectively reduces the elongation index in mouse hepatocytes H2.35, with an IC₅₀ of 30 nM. |
| In vivo | ELOVL6-IN-4 (compound 1w; 1-10 mg/kg; oral administration, single dose) effectively and dose-dependently inhibits the elongation index in the liver of male C57BL/6J mice [1]. Dosage: 1 mg/kg, 3 mg/kg, and 10 mg/kg; Administration: Oral, single dose. Result: Significant inhibition of hepatic elongation index. |
| Molecular Weight | 439.45 |
| Formula | C20H20F3N3O3S |
| Cas No. | 1170321-92-2 |
| Smiles | C(NC1=CC=C(C(F)(F)F)C=C1)(=O)N2[C@]3(C[C@H](S(=O)(=O)C4=CC=CC=N4)C[C@@]2(CC3)[H])[H] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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