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Sugemalimab
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Catalog No. T76714Cas No. 2256084-03-2
Sugemalimab (CS1001) is a fully humanized, full-length monoclonal antibody targeting PD-L1. It cross-links PD-L1-positive tumor cells with macrophages, inducing antibody-dependent cellular cytotoxicity. Sugemalimab is being studied for EGFR mutation-negative and ALK-negative metastatic non-small cell lung cancer (NSCLC), advanced solid tumors, and lymphoma.
Sugemalimab
Sugemalimab
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Purity: 95%
Catalog No. T76714Cas No. 2256084-03-2
Sugemalimab (CS1001) is a fully humanized, full-length monoclonal antibody targeting PD-L1. It cross-links PD-L1-positive tumor cells with macrophages, inducing antibody-dependent cellular cytotoxicity. Sugemalimab is being studied for EGFR mutation-negative and ALK-negative metastatic non-small cell lung cancer (NSCLC), advanced solid tumors, and lymphoma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $539 | - | In Stock | |
| 5 mg | $1,380 | - | In Stock | |
| 10 mg | $2,120 | - | In Stock | |
| 25 mg | $3,900 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95%
Appearance:Liquid
Color:Transparent
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| Description | Sugemalimab (CS1001) is a fully humanized, full-length monoclonal antibody targeting PD-L1. It cross-links PD-L1-positive tumor cells with macrophages, inducing antibody-dependent cellular cytotoxicity. Sugemalimab is being studied for EGFR mutation-negative and ALK-negative metastatic non-small cell lung cancer (NSCLC), advanced solid tumors, and lymphoma. |
| In vitro | Sugemalimab (CS1001) specifically binds PD-L1, competitively blocking human PD-L1 from interacting with PD-1 and CD80, thereby inducing CD4+ T lymphocyte proliferation and enhancing IFN-γ and IL-2 production. Sugemalimab lacks antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) [2]. |
| In vivo | In a human PD-1 knock-in mouse model, Sugemalimab (CS1001) significantly inhibited tumor growth in subcutaneously implanted MC38-hPD-L1 mouse colon carcinomas, increased the cytotoxic T cell/regulatory T cell ratio, and markedly upregulated M1 macrophages while downregulating myeloid-derived suppressor cells (MDSCs) [2]. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | PD-L1 |
| Cas No. | 2256084-03-2 |
| Isotype | Human IgG4 lambda |
| Storage | store at low temperature | -20°C for 20 months | Shipping with blue ice/Shipping at ambient temperature. |
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