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Sugemalimab

Catalog No. T76714 Copy Product Info
Purity: 95%
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Sugemalimab (CS1001) is a fully humanized, full-length monoclonal antibody targeting PD-L1. It cross-links PD-L1-positive tumor cells with macrophages, inducing antibody-dependent cellular cytotoxicity. Sugemalimab is being studied for EGFR mutation-negative and ALK-negative metastatic non-small cell lung cancer (NSCLC), advanced solid tumors, and lymphoma.

Sugemalimab

Copy Product Info
🥰Excellent
Catalog No. T76714

Sugemalimab (CS1001) is a fully humanized, full-length monoclonal antibody targeting PD-L1. It cross-links PD-L1-positive tumor cells with macrophages, inducing antibody-dependent cellular cytotoxicity. Sugemalimab is being studied for EGFR mutation-negative and ALK-negative metastatic non-small cell lung cancer (NSCLC), advanced solid tumors, and lymphoma.

Sugemalimab
Cas No. 2256084-03-2
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Pack SizePriceUSA StockGlobal StockQuantity
1 mg$539-In Stock
5 mg$1,380-In Stock
10 mg$2,120-In Stock
25 mg$3,900-In Stock
In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:95%
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Sugemalimab (CS1001) is a fully humanized, full-length monoclonal antibody targeting PD-L1. It cross-links PD-L1-positive tumor cells with macrophages, inducing antibody-dependent cellular cytotoxicity. Sugemalimab is being studied for EGFR mutation-negative and ALK-negative metastatic non-small cell lung cancer (NSCLC), advanced solid tumors, and lymphoma.
In vitro
Sugemalimab (CS1001) specifically binds PD-L1, competitively blocking human PD-L1 from interacting with PD-1 and CD80, thereby inducing CD4+ T lymphocyte proliferation and enhancing IFN-γ and IL-2 production. Sugemalimab lacks antibody-dependent cellular cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC) [2].
In vivo
In a human PD-1 knock-in mouse model, Sugemalimab (CS1001) significantly inhibited tumor growth in subcutaneously implanted MC38-hPD-L1 mouse colon carcinomas, increased the cytotoxic T cell/regulatory T cell ratio, and markedly upregulated M1 macrophages while downregulating myeloid-derived suppressor cells (MDSCs) [2].
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetPD-L1
Chemical Properties
Cas No.2256084-03-2
Antibody Information
IsotypeHuman IgG4 lambda
Storage & Solubility Information
Storagestore at low temperature | store at -80°C | Shipping with blue ice/Shipping at ambient temperature.

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