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NAT
🥰Excellent
Catalog No. T60667Cas No. 831243-31-3
Alias 2-(2-tert-butylphenoxy)-N-(4-hydroxyphenyl)acetamide
NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels and induces subsequent metabolic and transcriptional reprogramming. It exhibits neuroprotective effects in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model and may be employed in studies of neurodegenerative diseases or conditions associated with reduced NAD levels.
NAT
🥰Excellent
Purity: 99.65%
Catalog No. T60667Alias 2-(2-tert-butylphenoxy)-N-(4-hydroxyphenyl)acetamideCas No. 831243-31-3
NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels and induces subsequent metabolic and transcriptional reprogramming. It exhibits neuroprotective effects in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model and may be employed in studies of neurodegenerative diseases or conditions associated with reduced NAD levels.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $46 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $89 | In Stock |
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Purity:99.65%
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Product Introduction
Bioactivity
Chemical Properties
| Description | NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels and induces subsequent metabolic and transcriptional reprogramming. It exhibits neuroprotective effects in a chemotherapy-induced peripheral neuropathy (CIPN) mouse model and may be employed in studies of neurodegenerative diseases or conditions associated with reduced NAD levels. |
| Targets&IC50 | NAMPT:5.7 μM (EC50) |
| In vitro | NAT (10 µM) activates NAMPT (EC50=5.7 µM) and protects U2OS cells from the toxic effects of FK866. [1] |
| In vivo | In a chemotherapy-induced peripheral neuropathy (CIPN) mouse model, NAT (30 mg/kg, intraperitoneal injection, once daily for 2 weeks) exerted neuroprotective effects by elevating the mechanical hyperalgesia threshold. [1] |
| Synonyms | 2-(2-tert-butylphenoxy)-N-(4-hydroxyphenyl)acetamide |
| Molecular Weight | 299.36 |
| Formula | C18H21NO3 |
| Cas No. | 831243-31-3 |
| Smiles | O=C(NC1=CC=C(O)C=C1)COC=2C=CC=CC2C(C)(C)C |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: ≥ 80 mg/mL, Sonication is recommended. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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