Claudin-6 Protein, Human, Recombinant (GFP & His)

Name: Claudin-6 Protein, Human, Recombinant (GFP & His)
Brand: TargetMol
SKU: TMPY-06965
Rating: 4.5 (1 reviews)

(Synonyms: claudin 6) Copy Product Info

Synonyms: claudin 6

Catalog No. TMPY-06965 Copy Product Info

Claudin-6 Protein, Human, Recombinant (GFP & His) is expressed in HEK293 mammalian cells with GFP and His tag. The predicted molecular weight is 23.3 kDa and the accession number is P56747-1.

Pack Size	Price	USA Stock	Global Stock
10 µg	$1,650	7-10 days	7-10 days
20 µg	$2,800	7-10 days	7-10 days
50 µg	$5,720	7-10 days	7-10 days
100 µg	$9,830	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Bioactivity	Recombinant Human Claudin-6-Nanodisc(Full Length) Protein, Fluorescent at 5 μg/mL (100 μL/well) can bind Anti-Human Claudin6 Antibody, Human IgG1, the EC50 is 8-24 ng/mL.
Description	Claudin-6 Protein, Human, Recombinant (GFP & His) is expressed in HEK293 mammalian cells with GFP and His tag. The predicted molecular weight is 23.3 kDa and the accession number is P56747-1.
Species	Human
Expression System	HEK293 Cells
Tag	GFP, His
Accession Number	P56747-1
Construction	A DNA sequence encoding the Human CLDN6(P56747-1) (Met1-Val220) was expressed with a C-terminal GFP followed by a His tag.Nanodisc is a versatile tool for studying membrane proteins. Using styrene-maleic acid (SMA) copolymer, membrane proteins can be extracted directly from prokaryotic and eukaryotic expression systems in the absence of detergents to preserve the protein structure and function better. Compared to membrane scaffold proteins (MSPs) nanodiscs, SMA nanodiscs also have the advantage of preserving proteins' nature by maintaining native lipids surrounded without introducing any heterologous proteins, which allows studies of protein structure and functions in a native-like environment. Predicted N terminal: Met 1
Protein Purity	≥ 80 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 10 mM Hepes, 50 mM NaCl, 1% glycerin, pH 8.0.
Synonyms	claudin 6
Research Background	Claudin-6 (CLDN6) belongs to the claudins family and is a transmembrane protein found in tight junctions with two extracellular loops and intracellular N and C tails. CLDN6 modulates the ion- and charge-specific permeability of the paracellular pathway in most epithelial tissues. It regulates the paracellular flux of cations in the kidney through forming heterotypic strands with other claudins and has a role in maintaining the lung epithelial barrier function. The CLDN6 gene is adjacent to another family member, CLDN9, on chromosome 16. Certain CLDN6-positive cancers, encompassing ovarian, endometrial, and testicular malignancies, have been shown to have their proliferation and invasiveness suppressed upon CLDN6 silencing.

Chemical Properties

Molecular Weight

23.3 kDa (predicted); 37.2 kDa (reducing conditions)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 3 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: Claudin-6 Protein, Human, Recombinant (GFP & His) chemical structure | Claudin-6 Protein, Human, Recombinant (GFP & His) molecular weight