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Tanezumab
🥰Excellent
Catalog No. T78282Cas No. 880266-57-9
Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF (nerve growth factor). It inhibits the sensitisation and conduction of peripheral pain fibres by blocking the interaction between NGF and the p75 and TrkA receptors, thereby treating various acute and chronic pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.
Tanezumab
Tanezumab
🥰Excellent
Purity: 95%
Catalog No. T78282Cas No. 880266-57-9
Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF (nerve growth factor). It inhibits the sensitisation and conduction of peripheral pain fibres by blocking the interaction between NGF and the p75 and TrkA receptors, thereby treating various acute and chronic pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $172 | - | In Stock | |
| 5 mg | $433 | - | In Stock | |
| 10 mg | $695 | - | In Stock | |
| 25 mg | $1,060 | - | In Stock | |
| 50 mg | $1,430 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Concentration:5.51 mg/mL
Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF (nerve growth factor). It inhibits the sensitisation and conduction of peripheral pain fibres by blocking the interaction between NGF and the p75 and TrkA receptors, thereby treating various acute and chronic pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain. |
| In vitro | Methods: To evaluate the effect of Tanezumab on cell migration, MiaPaCa-2 and CFPAC-1 cells were treated with 100 ng/mL of the drug and incubated for 48 hours before performing a cell migration assay. Results: Tanezumab significantly inhibited the migration of MiaPaCa-2 and CFPAC-1 cells [3]. |
| In vivo | Methods: To evaluate the in vivo efficacy of Tanezumab, MiaPaCa-2 xenograft mouse models were administered 10 mg/kg subcutaneously once daily for 8 weeks. Results: Tanezumab reduced tumor volume and invasive nerve diameter, and alleviated hindlimb dysfunction [3]. |
| Cas No. | 880266-57-9 |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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