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D-(-)-Quinic acid

Name: D-(-)-Quinic acid
Brand: TargetMol
SKU: T2958
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2958Cas No. 77-95-2

Alias Quinic acid, Kinic acid, Chinic acid

D-(-)-Quinic acid (Kinic acid) is a cellular metal ion chelator, capable of promoting reactions with metal M(II,III) ions under pH-specific conditions. It may possess potent inhibition against alpha-mannosidase and alpha-fucosidase.

D-(-)-Quinic acid

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Purity: 99.88%

Catalog No. T2958Alias Quinic acid, Kinic acid, Chinic acidCas No. 77-95-2

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$33	In Stock	In Stock
500 mg	$68	In Stock	In Stock
1 g	$98	In Stock	In Stock
2 g	$143	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

D-(-)-Quinic acid AI Summary

D-(-)-Quinic acid exhibits multiple bioactivities, including inhibiting growth of MT-2 cells by 5% at a lethal dose concentration of 907.0 μM and inhibiting HIV-1-induced death of MT-2 cells at concentrations greater than 1823.0 μM. It also inhibits HIV-1 integrase in the disintegration reaction at 25 μM with 18.7% inhibition. Additionally, D-(-)-Quinic acid shows hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity in fasted Sprague-Dawley rat hepatocytes, affecting serum glutamic oxaloacetic transaminase and serum glutamic pyruvate transaminase releases with activities ranging from 15.5% to 21.9%. The compound inhibits collagenase type 5 with an IC50 greater than 500,000 nM. It also functions as an inhibitor in various assays, showing potencies ranging from 5623.4 nM to 100,000 nM against targets like JMJD2A-Tudor Domain, TGF-β, HCV, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). D-(-)-Quinic acid exhibits promising inhibitory effects on human amyloid beta (1–42) aggregation and oligomerization, with activity confirmed through thioflavin-T fluorescence assay, Western blot analysis, and thermodynamic stability assay. Furthermore, it inhibits sodium fluorescein uptake significantly in OATP1B3-transfected CHO cells (98.01%) and OATP1B1-transfected CHO cells (95.08%) at 10 μM. Additionally, it inhibits alpha-amylase with an IC50 of 13,000,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-(-)-Quinic acid (Kinic acid) is a cellular metal ion chelator, capable of promoting reactions with metal M(II,III) ions under pH-specific conditions. It may possess potent inhibition against alpha-mannosidase and alpha-fucosidase.
Synonyms	Quinic acid, Kinic acid, Chinic acid

Chemical Properties

Molecular Weight	192.17
Formula	C₇H₁₂O₆
Cas No.	77-95-2
Smiles	OC1CC(O)(CC(O)C1O)C(O)=O
Relative Density.	>= 670 - <= 750 kg/m3.

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 257.5 mg/mL (1339.96 mM), Sonication is recommended.

H2O: 100 mg/mL (520.37 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.2037 mL	26.0186 mL	52.0373 mL	260.1863 mL
5 mM	1.0407 mL	5.2037 mL	10.4075 mL	52.0373 mL
10 mM	0.5204 mL	2.6019 mL	5.2037 mL	26.0186 mL
20 mM	0.2602 mL	1.3009 mL	2.6019 mL	13.0093 mL
50 mM	0.1041 mL	0.5204 mL	1.0407 mL	5.2037 mL
100 mM	0.0520 mL	0.2602 mL	0.5204 mL	2.6019 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc