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EOS-62062

Catalog No. T4667 CAS 1258963-59-5

Pesampator (PF-04958242) is a potent, highly selective positive allosteric modulator of the AMPA receptor, also known as an AMPA potentiator, demonstrating an EC50 of 310 nM and a Ki of 170 nM [1].

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EOS-62062, CAS 1258963-59-5

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Pesampator (PF-04958242) is a potent, highly selective positive allosteric modulator of the AMPA receptor, also known as an AMPA potentiator, demonstrating an EC50 of 310 nM and a Ki of 170 nM [1].

In vivo

Pesampator administered subcutaneously (0.1-1 mg/kg) dose-dependently enhances cerebellum cGMP levels in CD-1 mice and at a dosage of 0.1-0.32 mg/kg, it shortens fall latency in C57BL/6J mice on an accelerating rotarod [1]. Furthermore, at dosages ranging from 0.001 to 0.01 mg/kg in male Sprague-Dawley rats, Pesampator counteracts the MK-801-induced (0.05 mg/kg; IV) decrease in paired-pulse facilitation (PPF) whether given cumulatively or as a single dose of 0.01 mg/kg intravenously [1]. At concentrations between 0.0032 and 0.032 mg/kg, it mitigates ketamine-caused disturbances in working memory in rats, evidenced by reduced errors in a radial arm maze [1]. Additionally, Pesampator exhibits a dose-dependent influence on the regional brain absorption of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) in rats at dosages of 0.027, 0.08, and 0.60 mg/kg [1].

Molecular Weight	392.49
Formula	C18H20N2O4S2
CAS No.	1258963-59-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EOS-62062 1258963-59-5 EOS 62062 EOS62062 inhibitor inhibit

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