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Bapotulimab
(Synonyms: BAY-1905254, BAY1905254) Copy Product Info
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Synonyms: BAY-1905254, BAY1905254
Catalog No. T78304 Copy Product Info
Purity: 95%
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Bapotulimab (BAY-1905254) is a human/mouse/monkey cross-reactive monoclonal antibody that targets and inhibits ILDR2 (immunoglobulin-like domain containing receptor 2), blocking its immunosuppressive activity for cancer immunotherapy. Bapotulimab promotes T-cell activation in mice, enhancing antigen-specific T-cell proliferation and cytotoxicity.
Bapotulimab
Cas No. 2359413-58-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $378 | - | In Stock | |
| 5 mg | $793 | - | In Stock | |
| 10 mg | $1,160 | - | In Stock | |
| 25 mg | $2,150 | - | In Stock | |
| 50 mg | $3,180 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.8% (SDS-PAGE); 97.8% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Chemical Properties
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| Description | Bapotulimab (BAY-1905254) is a human/mouse/monkey cross-reactive monoclonal antibody that targets and inhibits ILDR2 (immunoglobulin-like domain containing receptor 2), blocking its immunosuppressive activity for cancer immunotherapy. Bapotulimab promotes T-cell activation in mice, enhancing antigen-specific T-cell proliferation and cytotoxicity. |
| In vitro | Bapotulimab inhibits the immunosuppressive effect of ILDR2 on T cell activation. This agent exhibits cross-reactivity between humans and mice, attributed to a 98% sequence identity in the extracellular domain between human and murine orthologs of ILDR2 [1]. Bapotulimab (BAY-1905254; at concentrations of 5, 25, 100, or 500 ng/mL) enhances T cell activation and promotes the proliferation of antigen-specific T cells in vitro [1]. |
| In vivo | Bapotulimab (BAY-1905254; 10 mg/kg; intraperitoneal injection; administered on days 1 and 4) demonstrated a significant increase in antigen-specific T-cell proliferation and cytotoxicity [1]. |
| Synonyms | BAY-1905254, BAY1905254 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ILDR2 |
| Molecular Weight | 144.97 kDa |
| Cas No. | 2359413-58-2 |
| Isotype | Human IgG2 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Bapotulimab in vivo | Bapotulimab in vitro | Bapotulimab molecular weight
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