Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(RS)-AMPA ((±)-AMPA) monohydrate, a potent and selective agonist of the excitatory neurotransmitter L-glutamic acid, is a glutamate analogue. It specifically does not interact with the binding sites of kainic acid or NMDA receptors, highlighting its selectivity [1] [2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 885.00 | |
50 mg | 10-14 weeks | $ 1,150.00 | |
100 mg | 10-14 weeks | $ 1,740.00 |
Description | (RS)-AMPA ((±)-AMPA) monohydrate, a potent and selective agonist of the excitatory neurotransmitter L-glutamic acid, is a glutamate analogue. It specifically does not interact with the binding sites of kainic acid or NMDA receptors, highlighting its selectivity [1] [2]. |
In vitro | (RS)-AMPA monohydrate (10-3-10-4 M) leads to depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA monohydrate is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA monohydrate at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA monohydrate also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA monohydrate exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors [1]. |
Molecular Weight | 204.182 |
Formula | C7H12N2O5 |
CAS No. | 76463-67-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(RS)-AMPA monohydrate 76463-67-7 inhibitor inhibit