Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SK-575-NEG (compound 28), a methylated derivative of SK-575, results from the methylation of the piperidine-2,6-dione's amino group in SK-575, serving as a control compound. It exhibits strong binding affinity to PARP1, evidenced by an IC50 of 2.64 nM. However, SK-575-NEG proved to be ineffective in promoting PARP1 degradation in MDA-MB-436 and Capan-1 cells, even at concentrations as high as 1 μM [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 35 days | $ 935.00 |
Description | SK-575-NEG (compound 28), a methylated derivative of SK-575, results from the methylation of the piperidine-2,6-dione's amino group in SK-575, serving as a control compound. It exhibits strong binding affinity to PARP1, evidenced by an IC50 of 2.64 nM. However, SK-575-NEG proved to be ineffective in promoting PARP1 degradation in MDA-MB-436 and Capan-1 cells, even at concentrations as high as 1 μM [1]. |
Molecular Weight | 891 |
Formula | C48H55FN8O8 |
CAS No. | 2523017-04-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SK-575-NEG 2523017-04-9 inhibitor inhibit