Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME and safety profile [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | 10-14 weeks | $ 1,440.00 |
Description | PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME and safety profile [1]. |
In vitro | PF-06305591 (compound 9) exhibits a highly favorable profile, demonstrating selectivity for NaV channels, minimal hERG activity, effective passive permeability, and strong in vitro metabolic stability [1]. |
In vivo | PF-06305591 (compound 9) demonstrates significant bioavailability in rats and provides an opportunity to explore increased multiples of Nav1.8 blockade in clinical settings, thereby enabling a comprehensive assessment of NaV1.8's function in pain management [1]. |
Molecular Weight | 310.39 |
Formula | C15H26N4O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PF-06305591 dihydrate inhibitor inhibit