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Cimetidine sulfoxide

Name: Cimetidine sulfoxide
Brand: TargetMol
SKU: T38058
Rating: 4.5 (1 reviews)

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Catalog No. T38058Cas No. 54237-72-8

Cimetidine sulfoxide (Cimetidine sulphoxide), a metabolite of Cimetidine, is a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage [1].

Cimetidine sulfoxide

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Catalog No. T38058Cas No. 54237-72-8

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Product Introduction

Bioactivity

Description	Cimetidine sulfoxide (Cimetidine sulphoxide), a metabolite of Cimetidine, is a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage [1].
In vitro	Active transport of Cimetidine across the rat small intestine occurs at lower substrate concentrations (40 and 200 μM) but becomes obscured by passive transfer at higher concentrations (400 μM). Following specific incubations, Cimetidine sulfoxide is present[2].
In vivo	The enantiomeric composition of Cimetidine sulfoxide in male Wistar rats' urine (24 h) was analyzed following a 30 mg/kg oral dose of Cimetidine (po), resulting in an enantiomeric ratio of (+/-) 57:43[3].

Chemical Properties

Molecular Weight	268.34
Formula	C₁₀H₁₆N₆OS
Cas No.	54237-72-8
Smiles	CN\C(NC#N)=N/CCS(=O)Cc1[nH]cnc1C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.33 mg/mL (310.54 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (12.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7266 mL	18.6331 mL	37.2662 mL	186.3308 mL
5 mM	0.7453 mL	3.7266 mL	7.4532 mL	37.2662 mL
10 mM	0.3727 mL	1.8633 mL	3.7266 mL	18.6331 mL
20 mM	0.1863 mL	0.9317 mL	1.8633 mL	9.3165 mL
50 mM	0.0745 mL	0.3727 mL	0.7453 mL	3.7266 mL
100 mM	0.0373 mL	0.1863 mL	0.3727 mL	1.8633 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc