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Cimetidine sulfoxide

Catalog No. T38058 CAS 54237-72-8

Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, functioning as a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage[1].

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Cimetidine sulfoxide, CAS 54237-72-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, functioning as a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorrhage[1].
In vitro	Active transport of Cimetidine across the rat small intestine occurs at lower substrate concentrations (40 and 200 μM), becoming obscured by passive transfer at higher concentrations (400 μM). Following certain incubations, Cimetidine sulfoxide is present[2].
In vivo	The enantiomeric composition of Cimetidine sulfoxide in male Wistar rats' urine (24 h) was analyzed after administering a dose of 30 mg/kg of Cimetidine (po). The resulting enantiomeric ratio was established at (+/-) 57:43[3].

Molecular Weight	268.34
Formula	C10H16N6OS
CAS No.	54237-72-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (310.54 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Larsson R, et al. The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function. Br J Clin Pharmacol. 1982;13(2):163-170. 2. HE Barber, et al. The Transport of Cimetidine Across the Rat Small Intestine in Vitro. B r J Pharmacol. 1979 Jul;66(3):496P-497P. 3. Ryta A. Kuzel, et al. Investigations into the chirality of the metabolic sulfoxidation of cimetidine. Chirality (1994), 6(8), 607-14.

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Cimetidine sulfoxide 54237-72-8 inhibitor inhibit

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