L-Lysine-13C6-15N2 Hydrochloride is L-Lysine hydrochloride labeled with 13C and 15N isotopes. L-Lysine hydrochloride is an essential amino acid for humans and a common food additive. It stimulates the secretion of pepsin and gastric acid, enhances gastric juice secretion, and promotes growth and development in children.

L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) is the 15N-labeled L-Phenylalanine. L-Phenylalanine is an essential amino acid isolated from Escherichia coli . L-Phenylalanine is a α2δ subunit of voltage-dependent Ca + channels antagonist with a K i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) ( K B of 573 μM ) and non-NMDARs , respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

Riluzole-13C,15N2 (PK 26124-13C,15N2) is a 13C and 15N labeled form of Riluzole. Riluzole is a glutamate antagonist with anticonvulsant activity, inhibiting GABA reuptake and used in ALS research.

2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis.

Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50s = <0.09-1.78, 0.44-3.63, and 2.31-5.2 mg/animal, respectively). Formulations containing cefazolin have been used to treat a variety of bacterial infections.

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

L-Alanine-1-13C,15N is an isotopically labeled version of L-Alanine, marked with both 13C and 15N. L-Alanine is a non-essential amino acid involved in carbohydrate and acid metabolism, enhancing immune function, and supplying energy to muscle tissue, the brain, and the central nervous system.

L-Leucine-1-13C,15N is L-Leucine that is labeled with 13C and 15N. L-Leucine is an essential branched-chain amino acid (BCAA) known to activate the mTOR signaling pathway.

Hypoxanthine-15N4 is the 15N-labeled form of Hypoxanthine. This compound is a purine derivative and serves as a potential free radical generator, as well as an indicator of hypoxia.

Cytidine 5′-monophosphate-13C9,15N3(5'-Cytidylic acid-13C9,15N3dilithium; 5'-CMP-13C9,15N3) dilithium is the isotopically labeled form of cytidine 5'-monophosphate with carbon-13 and nitrogen-15. Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide that serves as a monomer in RNA, and it comprises a cytosine base, a ribose sugar, and a phosphate group.

Pantothenic acid-13C3,15N (hemicalcium) is a version of D-Pantothenic acid labeled with 13C and 15N isotopes. D-Pantothenic acid is an essential micronutrient, serving as a precursor to coenzyme A (CoA). It plays a crucial role in numerous biological processes, including the regulation of carbohydrate, lipid, protein, and nucleic acid metabolism.

Allopurinol-13C,15N2 is an isotopically labeled form of Allopurinol with Carbon-13 and Nitrogen-15. Allopurinol is an effective oral xanthine oxidase inhibitor with an IC50 value range of 0.2-50 μM, used in the study of hyperuricemia and gout. It reduces the expression of HIF-1α and HIF-2α proteins and exhibits antidepressant and antinociceptive properties. Additionally, Allopurinol has anti-leishmanial effects.

Liraglutide-13C6,15N (TFA) is a version of Liraglutide labeled with 13C and 15N. Liraglutide acts as a glucagon-like peptide-1 (GLP-1) receptor agonist and is clinically used for the treatment of type 2 diabetes.

L-Tryptophan-13C11,15N2 is an isotopically labeled version of L-Tryptophan, featuring both 13C and 15N markers. L-Tryptophan (Tryptophan) is an essential amino acid that serves as a precursor for serotonin, melatonin, and vitamin B3.

Liraglutide-13C5,15N (tetraTFA) is a version of Liraglutide labeled with 13C and 15N isotopes. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which is clinically used for the treatment of type 2 diabetes.

Allantoin-13C2,15N4 is a variant of Allantoin labeled with 13C and 15N. Known as a skin conditioning agent, Allantoin promotes skin health and stimulates the growth of new, healthy tissue.

L-Arginine-13C6,15N4,d7 (hydrochloride) is an L-Arginine hydrochloride compound labeled with 13C, 15N, and deuterium. This compound, known as L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride), serves as a nitrogen donor for nitric oxide synthesis and acts as a vasodilator.

Adenosine-13C10,15N5 is adenosine labeled with 13C and 15N isotopes. Adenosine (adenine riboside) is a widely present endogenous secretion that exerts its effects through four G protein-coupled receptors [A1, A2A, A2B, and A3]. It influences nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

Inosinic acid-15N4dilithium (5'-IMP-15N4 (dilithium); IMP-15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-15N4 (dilithium)) is a 15N-labeled derivative of inosinic acid, an endogenous metabolite.

Glycine-15N is a 15N labeled form of glycine. Glycine functions as an inhibitory neurotransmitter in the central nervous system and acts as a co-agonist with glutamate, potentially enhancing the excitatory activity of the NMDA (N-methyl-D-aspartic acid) receptors.

L-Serine-13C3,15N is an isotopically labeled version of L-Serine, featuring both 13C and 15N markers. L-Serine ((-)-Serine) is a non-essential amino acid that plays a critical role in cell proliferation.

L-Alanine-15N is an L-Alanine compound labeled with the isotope 15N. L-Alanine, a non-essential amino acid, plays a role in sugar and acid metabolism, strengthens the immune system, and supplies energy to muscle tissue, the brain, and the central nervous system.

N-Acetyl-D-mannosamine-15N is the 15N-labeled version of N-Acetyl-D-mannosamine (ManNAc). This compound serves as an essential precursor for N-acetylneuraminic acid (NeuAc) and acts as a specific monomer in bacterial capsular poly(sialic acid) [PA]. N-Acetyl-D-mannosamine (ManNAc) is metabolized by GNE and GlcNAc 2-epimerase (renin-binding protein, RnBP) into ManNAc-6-phosphate and GlcN.

L-Isoleucine-15N is an isotopically labeled variant of L-Isoleucine, marked with 15N. It is characterized as a nonpolar, hydrophobic amino acid and is considered essential.