L-Lysine-13C6-15N2 Hydrochloride is L-Lysine hydrochloride labeled with 13C and 15N isotopes. L-Lysine hydrochloride is an essential amino acid for humans and a common food additive. It stimulates the secretion of pepsin and gastric acid, enhances gastric juice secretion, and promotes growth and development in children.

L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) is the 15N-labeled L-Phenylalanine. L-Phenylalanine is an essential amino acid isolated from Escherichia coli . L-Phenylalanine is a α2δ subunit of voltage-dependent Ca + channels antagonist with a K i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) ( K B of 573 μM ) and non-NMDARs , respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

Riluzole-13C,15N2 (PK 26124-13C,15N2) is a 13C and 15N labeled form of Riluzole. Riluzole is a glutamate antagonist with anticonvulsant activity, inhibiting GABA reuptake and used in ALS research.

2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis.

Vadadustat-13C2-15N is 13C and 15N labeled Vadadustat. Vadadustat has a CAS number of 1000025-07-9. Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

Roxadustat-13C-15N is 13C and 15N labeled Roxadustat.

Upadacitinib-15N-d2 the 15N and deuterated compound of Upadacitinib. Upadacitinib has a CAS number of 1310726-60-3. Upadacitinib (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.

L-Valine-13C5-15N is the 13C and 15N labeled compound of L-Valine. L-Valine has a CAS number of 72-18-4. A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50s = <0.09-1.78, 0.44-3.63, and 2.31-5.2 mg/animal, respectively). Formulations containing cefazolin have been used to treat a variety of bacterial infections.

Pantothenic acid-13C3,15N (hemicalcium) is a version of D-Pantothenic acid labeled with 13C and 15N isotopes. D-Pantothenic acid is an essential micronutrient, serving as a precursor to coenzyme A (CoA). It plays a crucial role in numerous biological processes, including the regulation of carbohydrate, lipid, protein, and nucleic acid metabolism.

Cytidine 5′-monophosphate-13C9,15N3(5'-Cytidylic acid-13C9,15N3dilithium; 5'-CMP-13C9,15N3) dilithium is the isotopically labeled form of cytidine 5'-monophosphate with carbon-13 and nitrogen-15. Cytidine 5'-monophosphate (5'-Cytidylic acid) is a nucleotide that serves as a monomer in RNA, and it comprises a cytosine base, a ribose sugar, and a phosphate group.

L-Alanine-1-13C,15N is an isotopically labeled version of L-Alanine, marked with both 13C and 15N. L-Alanine is a non-essential amino acid involved in carbohydrate and acid metabolism, enhancing immune function, and supplying energy to muscle tissue, the brain, and the central nervous system.

Adenosine-13C10,15N5 is adenosine labeled with 13C and 15N isotopes. Adenosine (adenine riboside) is a widely present endogenous secretion that exerts its effects through four G protein-coupled receptors [A1, A2A, A2B, and A3]. It influences nearly all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

Inosinic acid-15N4dilithium (5'-IMP-15N4 (dilithium); IMP-15N4 (dilithium); Inosine 5'-(dihydrogen phosphate)-15N4 (dilithium)) is a 15N-labeled derivative of inosinic acid, an endogenous metabolite.

Glycine-15N is a 15N labeled form of glycine. Glycine functions as an inhibitory neurotransmitter in the central nervous system and acts as a co-agonist with glutamate, potentially enhancing the excitatory activity of the NMDA (N-methyl-D-aspartic acid) receptors.

L-Aspartic acid-13C4,15N is an isotopically labeled form of L-aspartic acid, containing both 13C and 15N. L-Aspartic acid is an amino acid recognized as a precursor active molecule for targeted molecular delivery within the colon.

Guanosine-13C10,15N5 is a version of Guanosine labeled with isotopes 13C and 15N. Guanosine (DL-Guanosine) is a type of nucleoside, consisting of guanine attached to a ribose ring through a β-N9-glycosidic bond. It has activity against HSV.

Liraglutide-13C5,15N (tetraTFA) is a version of Liraglutide labeled with 13C and 15N isotopes. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which is clinically used for the treatment of type 2 diabetes.

L-Arginine-13C6,15N4,d7 (hydrochloride) is an L-Arginine hydrochloride compound labeled with 13C, 15N, and deuterium. This compound, known as L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride), serves as a nitrogen donor for nitric oxide synthesis and acts as a vasodilator.

L-Tryptophan-13C11,15N2 is an isotopically labeled version of L-Tryptophan, featuring both 13C and 15N markers. L-Tryptophan (Tryptophan) is an essential amino acid that serves as a precursor for serotonin, melatonin, and vitamin B3.

L-Leucine-13C6,15N is L-Leucine tagged with both 13C and 15N isotopes. L-Leucine is an essential branched-chain amino acid (BCAA) that activates the mTOR signaling pathway.

Allantoin-13C2,15N4 is a variant of Allantoin labeled with 13C and 15N. Known as a skin conditioning agent, Allantoin promotes skin health and stimulates the growth of new, healthy tissue.

Cytidine-13C9,15N3 is a form of cytidine labeled with 13C and 15N isotopes. As a pyrimidine nucleoside, cytidine is a component of RNA and serves as a precursor to uridine. It regulates the astroglial glutamate cycle, influences brain phospholipid metabolism, catecholamine synthesis, and mitochondrial function.