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APX2009

Name: APX2009
Brand: TargetMol
SKU: T70733
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: APX 2009) Copy Product Info

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Synonyms: APX 2009

Catalog No. T70733 Copy Product Info

Purity: 99.50%

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APX2009 is a second-generation redox-specific inhibitor of apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1). APX2009 significantly reduces NFκB transcriptional activity, survivin mRNA expression, and survivin protein levels. APX2009 also decreases prostate cancer cell proliferation and induces cell-cycle arrest. These findings support the application of APX2009 in studies of redox signaling, transcriptional regulation, cancer cell biology, and APE1/Ref-1-mediated molecular pathways.

Cas No. 1415030-15-7

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Pack Size	Price	USA Stock	Global Stock
1 mg	$41	-	In Stock
5 mg	$97	-	In Stock
10 mg	$139	-	In Stock
25 mg	$233	-	In Stock
50 mg	$397	-	In Stock
100 mg	$678	-	In Stock
1 mL x 10 mM (in DMSO)	$98	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.50%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Synonyms

APX 2009

Chemical Properties

Molecular Weight	355.43
Formula	C₂₁H₂₅NO₄
Cas No.	1415030-15-7
Smiles	O=C1C(OC)=C(C=C(C(=O)N(CC)CC)CCC)C(=O)C=2C=CC=CC12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (225.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8135 mL	14.0675 mL	28.1349 mL	140.6747 mL
5 mM	0.5627 mL	2.8135 mL	5.6270 mL	28.1349 mL
10 mM	0.2813 mL	1.4067 mL	2.8135 mL	14.0675 mL
20 mM	0.1407 mL	0.7034 mL	1.4067 mL	7.0337 mL
50 mM	0.0563 mL	0.2813 mL	0.5627 mL	2.8135 mL
100 mM	0.0281 mL	0.1407 mL	0.2813 mL	1.4067 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc