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α,α-Trehalose 6-phosphate potassium (Synonyms: Tre6P potassium)

Name: α,α-Trehalose 6-phosphate potassium
Brand: TargetMol
SKU: T78471
Price: 61 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T78471 Copy Product Info

Purity: 99.97%

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α,α-Trehalose 6-phosphate potassium is a glucose analogue with potent anti-hyperglycemic activity. It serves as a central signaling molecule in carbon metabolism regulation, particularly in plants and microorganisms, where it functions as a sensor for sucrose or glucose levels. In vivo, Tre6P is rapidly converted to its end product, α,α'-trehalose, by the enzyme α,α-Trehalose 6-phosphate phosphatase (T6PP). Beyond its role as a metabolic intermediate, Tre6P demonstrates potential in diabetic models to alleviate hyperglycemic symptoms by modulating glucose homeostasis.

α,α-Trehalose 6-phosphate potassium

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Catalog No. T78471

Synonyms Tre6P potassium

Cas No. 136632-28-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$61	-	In Stock
5 mg	$147	-	In Stock
10 mg	$227	-	In Stock
25 mg	$455	-	In Stock
50 mg	$728	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	α,α-Trehalose 6-phosphate potassium is a glucose analogue with potent anti-hyperglycemic activity. It serves as a central signaling molecule in carbon metabolism regulation, particularly in plants and microorganisms, where it functions as a sensor for sucrose or glucose levels. In vivo, Tre6P is rapidly converted to its end product, α,α'-trehalose, by the enzyme α,α-Trehalose 6-phosphate phosphatase (T6PP). Beyond its role as a metabolic intermediate, Tre6P demonstrates potential in diabetic models to alleviate hyperglycemic symptoms by modulating glucose homeostasis.
In vivo	α,α-Trehalose 6-phosphate potassium exhibits significant hypoglycemic activity in alloxan-induced diabetic rats, alleviating hyperglycemia. The effect may involve suppression of endogenous glucose production and enhanced peripheral glucose utilization [2]。
Synonyms	Tre6P potassium

Chemical Properties

Molecular Weight	498.46
Formula	C₁₂H₂₁K₂O₁₄P
Cas No.	136632-28-5
Smiles	O=P([O-])([O-])OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@@H]1O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO.[K+].[K+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (160.49 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0062 mL	10.0309 mL	20.0618 mL	100.3090 mL
5 mM	0.4012 mL	2.0062 mL	4.0124 mL	20.0618 mL
10 mM	0.2006 mL	1.0031 mL	2.0062 mL	10.0309 mL
20 mM	0.1003 mL	0.5015 mL	1.0031 mL	5.0154 mL
50 mM	0.0401 mL	0.2006 mL	0.4012 mL	2.0062 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0031 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

EndogenousMetaboliteEndogenous Metabolitealpha,alpha-Trehalose 6-phosphate potassiuma,a-Trehalose 6-phosphate potassium

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