STAT3-IN-24, cell-permeable

Name: STAT3-IN-24, cell-permeable
Brand: TargetMol
SKU: TP2628
Rating: 4.5 (1 reviews)

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Catalog No. TP2628Cas No. 400628-16-2

Alias STAT3 PI, PpYLKTK-mtsSTAT3 PI

STAT3-IN-24, a cell-permeable (PpYLKTK-mts) peptide inhibitor, obstructs the recruitment of STAT3 to Jak2 and inhibits the phosphorylation of Y705, thereby preventing STAT3 dimerization and nuclear translocation [1].

STAT3-IN-24, cell-permeable

😃Good

Catalog No. TP2628Alias STAT3 PI, PpYLKTK-mtsSTAT3 PICas No. 400628-16-2

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	Inquiry
50 mg	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	STAT3-IN-24, a cell-permeable (PpYLKTK-mts) peptide inhibitor, obstructs the recruitment of STAT3 to Jak2 and inhibits the phosphorylation of Y705, thereby preventing STAT3 dimerization and nuclear translocation [1].
Synonyms	STAT3 PI, PpYLKTK-mtsSTAT3 PI

Chemical Properties

Molecular Weight	1958.32
Formula	C₉₂H₁₅₇N₂₀O₂₄P
Cas No.	400628-16-2
Sequence	Pro-{Tyr(PO3H2)}-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro
Sequence Short	P-{Tyr(PO3H2)}-LKTKAAVLLPVLLAAP

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc