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PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)

Catalog No. T36427

Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, SK-N-MC, and T47D cells).

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PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) Chemical Structure

PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt), CAS N/A

Pack Size	Availability	Price/USD	Quantity
500 μg	35 days	$ 445.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

In vivo, in newborn pigs, PACAP (6-27) (10 μM) inhibits vasodilation of pial arterioles induced by PACAP (1-27) and PACAP (1-38) . It also inhibits PACAP (1-27)-stimulated increases in plasma insulin and glucagon levels and pancreatic venous blood flow in dogs when administered locally to the pancreas at a dose of 500 μg.

Molecular Weight

N/A

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 1 mg/mL

Related Products

Related compounds with same targets

PACAP (1-27), human, ovine, rat acetate PACAP 1-38 acetate PACAP-related Peptide (rat) (trifluoroacetate salt) PAC1R antagonist 1 PACAP-38 (31-38), human, mouse, rat acetate PACAP (6-38), human, ovine, rat acetate PACAP-related Peptide (human) (trifluoroacetate salt) PA-8

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) GPCR/G Protein PACAP PACAP (627) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) PACAP (6 27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt) inhibitor inhibit

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