Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyproheptadine is a potent and orally active antagonist of the 5-HT 2A receptor. Cyproheptadine has antidepressant and antiserotonergic effects. Cyproheptadine also has antiplatelet and thromboprotective activities that can be used in thromboembolic disorders research [1] [2].
Pack Size | Availability | Price/USD | Quantity |
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500 mg | 6-8 weeks | $ 1,130.00 |
Description | Cyproheptadine is a potent and orally active antagonist of the 5-HT 2A receptor. Cyproheptadine has antidepressant and antiserotonergic effects. Cyproheptadine also has antiplatelet and thromboprotective activities that can be used in thromboembolic disorders research [1] [2]. |
In vitro | Cyproheptadine, in concentrations ranging from 0.01 to 100 nM and applied for 1 minute, effectively inhibits serotonin-enhanced ADP-induced platelet aggregation in mice in a dose-dependent manner in vitro [2]. At a concentration of 10 nM, it also inhibits serotonin-enhanced ADP-induced tyrosine phosphorylation in platelets at 1 μM ADP and 15 μM serotonin levels in vitro [2]. Furthermore, Cyproheptadine suppresses PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in human platelets in vitro [2]. |
In vivo | Cyproheptadine (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo [2]. Animal Model: C57BL/6 mice (8-10 weeks old) [2] Dosage: 1 mg/kg Administration: Intraperitoneal injection; daily, for 5 days Result: Prolonged occlusion times and tail bleeding times in mice. |
Molecular Weight | 287.4 |
Formula | C21H21N |
CAS No. | 129-03-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Cyproheptadine 129-03-3 inhibitor inhibit