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Malabaricone A

Name: Malabaricone A
Brand: TargetMol
SKU: TN6770
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6770Cas No. 63335-23-9

Malabaricone A is a bioactive chemical.

Malabaricone A

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Purity: 99.12%

Catalog No. TN6770Cas No. 63335-23-9

Malabaricone A is a bioactive chemical.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$119	In Stock	In Stock
10 mg	$176	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$441	In Stock	In Stock
100 mg	$592	-	In Stock
1 mL x 10 mM (in DMSO)	$102	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.12%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Malabaricone A AI Summary

Malabaricone A is a multifunctional bioactive molecule exhibiting various pharmacological effects. It demonstrates cytotoxicity against human MCF7 cells, showing 12.0% activity at 50 μM after 72 hours, as assessed by the MTT assay. The compound also possesses notable antimycobacterial activity against Mycobacterium tuberculosis H37Ra, with a Minimum Inhibitory Concentration (MIC) of 25.0 μg/mL. In terms of enzyme inhibition, Malabaricone A is a potent inhibitor of both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), with IC50 values of 39.21 μM and 1.31 μM, respectively, and a high selectivity towards AChE, indicated by a selectivity index of 32.95. Additionally, it shows significant inhibition of porcine pancreatic alpha-amylase (IC50: 19070.0 nM), rat intestinal alpha-glucosidase (IC50: 91440.0 nM), and exhibits antiglycation activity in bovine serum albumin (IC50: 19280.0 nM). The compound has antidiabetic properties, enhancing glucose uptake in rat L6 cells with activities of 32.9%, 33.4%, and 36.7% at concentrations of 10 μM, 25 μM, and 50 μM, respectively. Furthermore, Malabaricone A noncompetitively inhibits SMS1 and SMS2 enzymes, showing higher potency against SMS2 (IC50: 1000.0 nM) compared to SMS1 (IC50: 2000.0 nM), as determined using C6-NBD-ceramide as the substrate in HPLC analysis..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Malabaricone A is a bioactive chemical.

Chemical Properties

Molecular Weight	326.43
Formula	C₂₁H₂₆O₃
Cas No.	63335-23-9
Smiles	C(CCCCCCCCC1=CC=CC=C1)(=O)C2=C(O)C=CC=C2O
Relative Density.	1.11g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (168.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0634 mL	15.3172 mL	30.6344 mL	153.1722 mL
5 mM	0.6127 mL	3.0634 mL	6.1269 mL	30.6344 mL
10 mM	0.3063 mL	1.5317 mL	3.0634 mL	15.3172 mL
20 mM	0.1532 mL	0.7659 mL	1.5317 mL	7.6586 mL
50 mM	0.0613 mL	0.3063 mL	0.6127 mL	3.0634 mL
100 mM	0.0306 mL	0.1532 mL	0.3063 mL	1.5317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc