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MSLN/Mesothelin Protein, Human, Recombinant (hFc)

(Synonyms: SMRP, MPF, Mesothelin) Copy Product Info

Synonyms: SMRP, MPF, Mesothelin

Catalog No. TMPY-02951 Copy Product Info
Mesothelin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.7 kDa and the accession number is Q13421-2.
Pack SizePriceUSA StockGlobal StockQuantity
5 µg$687-10 days7-10 days
10 µg$1087-10 days7-10 days
20 µg$1787-10 days7-10 days
50 µg$3597-10 days7-10 days
100 µg$6967-10 days7-10 days
200 µg$1,0607-10 days7-10 days
500 µg$2,2307-10 days7-10 days
1 mg$4,5307-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Mesothelin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.7 kDa and the accession number is Q13421-2.
Species
Human
Expression System
HEK293 Cells
TagC-hFc
Accession NumberQ13421-2
ConstructionA DNA sequence encoding the human MSLN (Q13421-2) (Met1-Arg286) was expressed, fused with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Leu 37
Protein Purity
> 95 % as determined by SDS-PAGE
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
SynonymsSMRP, MPF, Mesothelin
Research Background
The megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known. Megakaryocyte potentiating factor is highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). It interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Chemical Properties
Molecular Weight53.7 kDa (predicted); 56 kDa (reducing conditions)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: MSLN/Mesothelin Protein, Human, Recombinant (hFc) chemical structure | MSLN/Mesothelin Protein, Human, Recombinant (hFc) molecular weight