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BAY-252

Name: BAY-252
Brand: TargetMol
SKU: T78148
Rating: 4.5 (1 reviews)

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Catalog No. T78148Cas No. 2639638-67-6

Alias BAY252

BAY-252 is a potent inhibitor of branched-chain amino acid transaminases 1 (BCAT1) and BCAT2, with IC50 of 2 μM for both enzymes. In addition to its inhibitory properties, BAY-252 serves as a chemical probe in cancer research, aiding in the investigation of metabolic pathways involving branched-chain amino acids.

BAY-252

😃Good

Catalog No. T78148Alias BAY252Cas No. 2639638-67-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	Inquiry	8-10 weeks	8-10 weeks
50 mg	Inquiry	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BAY-252 is a potent inhibitor of branched-chain amino acid transaminases 1 (BCAT1) and BCAT2, with IC50 of 2 μM for both enzymes. In addition to its inhibitory properties, BAY-252 serves as a chemical probe in cancer research, aiding in the investigation of metabolic pathways involving branched-chain amino acids.
In vitro	BAY-252 inhibits the proliferation of MDA-MB-231 cells with an IC50 value of 2 μM [1].
Synonyms	BAY252

Chemical Properties

Molecular Weight	446.81
Formula	C₂₂H₁₄ClF₃N₂O₃
Cas No.	2639638-67-6
Smiles	O=C1C=C(NC(=O)N1C2=CC(OC=3C=CC=CC3C)=C(Cl)C=4C=CC=CC42)C(F)(F)F
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (223.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 4 mg/mL (8.95 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2381 mL	11.1904 mL	22.3809 mL	111.9044 mL
5 mM	0.4476 mL	2.2381 mL	4.4762 mL	22.3809 mL
10 mM	0.2238 mL	1.1190 mL	2.2381 mL	11.1904 mL
20 mM	0.1119 mL	0.5595 mL	1.1190 mL	5.5952 mL
50 mM	0.0448 mL	0.2238 mL	0.4476 mL	2.2381 mL
100 mM	0.0224 mL	0.1119 mL	0.2238 mL	1.1190 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc