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IMMH001

Name: IMMH001
Brand: TargetMol
SKU: T61621
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: SYL930, IMMH 001) Copy Product Info

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Synonyms: SYL930, IMMH 001

Catalog No. T61621 Copy Product Info

Purity: 99.67%

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IMMH001, also known as SYL930, is an orally active compound that functions as a highly selective agonist of sphingosine-1-phosphate receptor 1 (S1P1). IMMH001 effectively reduces the levels of multiple chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 is applicable to investigations involving rheumatoid arthritis (RA), immune cell trafficking, inflammatory signaling cascades, and sphingosine-1-phosphate receptor-mediated immunoregulation.

Cas No. 1418093-75-0

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Pack Size	Price	USA Stock	Global Stock
1 mg	$117	-	In Stock
5 mg	$289	-	In Stock
10 mg	$463	-	In Stock
25 mg	$928	-	In Stock
1 mL x 10 mM (in DMSO)	$318	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.67%

Appearance:Solid

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	IMMH001, also known as SYL930, is an orally active compound that functions as a highly selective agonist of sphingosine-1-phosphate receptor 1 (S1P1). IMMH001 effectively reduces the levels of multiple chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 is applicable to investigations involving rheumatoid arthritis (RA), immune cell trafficking, inflammatory signaling cascades, and sphingosine-1-phosphate receptor-mediated immunoregulation.
In vivo	IMMH001 is metabolized into its active monophosphate ester form, (S)-IMMH001-P, by the action of sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2) in vivo [1]. IMMH001 effectively diminishes disease manifestations mediated by both Th1 (IL-1β, IL-18, and IP10) and Th2 (IL-5) cells in inflamed joints [2]. IMMH001 (0.3-2.4 mg/kg, Orally; twice a week, for 28 days, AA rats; for 30 days, CIA rats) significantly alleviates joint damage in these models [2].
Synonyms	SYL930, IMMH 001

Chemical Properties

Molecular Weight	380.48
Formula	C₂₃H₂₈N₂O₃
Cas No.	1418093-75-0
Smiles	OCC(N)(CO)CCC=1C=CC(=CC1)C=2C=CC(=CC2)C=3N=C(OC3)CCC

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (210.26 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6283 mL	13.1413 mL	26.2826 mL	131.4130 mL
5 mM	0.5257 mL	2.6283 mL	5.2565 mL	26.2826 mL
10 mM	0.2628 mL	1.3141 mL	2.6283 mL	13.1413 mL
20 mM	0.1314 mL	0.6571 mL	1.3141 mL	6.5706 mL
50 mM	0.0526 mL	0.2628 mL	0.5257 mL	2.6283 mL
100 mM	0.0263 mL	0.1314 mL	0.2628 mL	1.3141 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: IMMH001 chemical structure | IMMH001 in vivo | IMMH001 formula | IMMH001 molecular weight