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GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His)
(Synonyms: TRNR2, TGF-β-related neurotrophic factor receptor 2, TGF-beta-related neurotrophic factor receptor 2, RETL2, RET ligand 2, Neurturin receptor α, Neurturin receptor alpha, GDNFR-β, GDNFR-beta, GDNFRB) Copy Product InfoSynonyms: TRNR2, TGF-β-related neurotrophic factor receptor 2, TGF-beta-related neurotrophic factor receptor 2, RETL2, RET ligand 2, Neurturin receptor α, Neurturin receptor alpha, GDNFR-β, GDNFR-beta, GDNFRB
Catalog No. TMPJ-00290 Copy Product Info
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $39 | 35 days | 35 days | |
| 10 µg | $60 | 35 days | 35 days | |
| 20 µg | $83 | 35 days | 35 days | |
| 50 µg | $129 | 35 days | 35 days | |
| 100 µg | $219 | 35 days | 35 days | |
| 200 µg | $383 | 35 days | 35 days | |
| 500 µg | $806 | 35 days | 35 days | |
| 1 mg | $1,300 | 35 days | 35 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-hFc-6xHis |
| Accession Number | O00451 |
| Amino Acid | Ser22-Ser441 |
| Construction | Ser22-Ser441 |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, pH 8.0. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | TRNR2, TGF-β-related neurotrophic factor receptor 2, TGF-beta-related neurotrophic factor receptor 2, RETL2, RET ligand 2, Neurturin receptor α, Neurturin receptor alpha, GDNFR-β, GDNFR-beta, GDNFRB |
| Research Background | GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. |
| Molecular Weight | 120 KDa (reducing condition) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His) chemical structure | GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His) molecular weight
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