GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | 5 days | $ 60.00 | |
50 μg | 5 days | $ 129.00 | |
500 μg | 5 days | $ 806.00 | |
1 mg | 5 days | $ 1,300.00 |
Description | GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. |
Species | Human |
Expression System | Human Cells |
Tag | C-Fc-6His |
Accession Number | O00451 |
Synonyms | TRNR2, GDNFR-beta, TGF-β-related neurotrophic factor receptor 2, GDNFRB, RET ligand 2, RETL2, Neurturin receptor alpha, TGF-beta-related neurotrophic factor receptor 2, GDNFR-β, Neurturin receptor α |
Amino Acid | Ser22-Ser441 |
Construction | Recombinant Human Glial Cell line-derived Neurotrophic Factor Receptor Alpha 2 is produced by our Mammalian expression system and the target gene encoding Ser22-Ser441 is expressed with a human IgG1 Fc, 6His tag at the C-terminus. |
Molecular Weight | 120 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Research Background | GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signaling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. |
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Please read the User Guide of Recombinant Proteins for more specific information.
GFR Alpha-2/GFRA2 Protein, Human, Recombinant (hFc & His) TRNR2 GDNFR-beta TGF-β-related neurotrophic factor receptor 2 GDNFRB RETL-2 RET ligand 2 RETL2 Neurturin receptor alpha TGF-beta-related neurotrophic factor receptor 2 GDNFR-β RETL 2 TRNR 2 TRNR-2 TGF-b-related neurotrophic factor receptor 2 Neurturin receptor α recombinant recombinant-proteins proteins protein