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P110

Name: P110
Brand: TargetMol
SKU: TP1947
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TP1947 Copy Product Info

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P110 heptapeptide is a specific peptide inhibitor that interacts with Drp1/Fis1 (IC₅₀=1.8 μM). By competitively blocking the binding of Drp1 to Fis1, P110 heptapeptide inhibits pathological mitochondrial fission while preserving the physiological function of Drp1, thereby reducing pathological features in numerous models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide exhibits neuroprotective, anti-inflammatory, and anti-sepsis activity and can be used in research on neurodegenerative diseases and conditions associated with mitochondrial dysfunction.

P110

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Catalog No. TP1947

Cas No. 1411976-18-5

Pack Size	Price	USA Stock	Global Stock
1 mg	$35	-	In Stock
5 mg	$78	-	In Stock
10 mg	$121	Inquiry	Inquiry
25 mg	$239	Inquiry	Inquiry
100 mg	$541	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	P110 heptapeptide is a specific peptide inhibitor that interacts with Drp1/Fis1 (IC₅₀=1.8 μM). By competitively blocking the binding of Drp1 to Fis1, P110 heptapeptide inhibits pathological mitochondrial fission while preserving the physiological function of Drp1, thereby reducing pathological features in numerous models of neurodegeneration, ischemia, and sepsis. P110 heptapeptide exhibits neuroprotective, anti-inflammatory, and anti-sepsis activity and can be used in research on neurodegenerative diseases and conditions associated with mitochondrial dysfunction.
Targets&IC50	Drp1:1.8 μM
In vitro	Methods: RAW264.7 cells were co-treated with P110 (1 μM) and LPS (10 ng/mL) for 16 h, and mitochondrial membrane potential was measured using JC-1 fluorescence. Results: P110 reduced Drp1 mitochondrial localization and restored the LPS-induced increase in membrane potential and decline in respiratory function. [1] Methods: H9c2 cells were treated with P110 (2 μM) and LPS (2 μg/mL) for 24 h. Anti-Drp1 and anti-Fis1 immunostaining was performed, followed by confocal z-stack imaging to determine the ratio of Drp1 foci to mitochondrial area. Results: LPS increased Drp1 mitochondrial localization, while P110 reduced Drp1 mitochondrial localization to levels below those of the control.[2]
In vivo	Methods: BALB/c mice were administered LPS (1 mg/kg) and P110 (0.5 mg/kg/day) intraperitoneally. After 18 hours of tolerance induction, blood samples were collected 90 minutes following treatment with a high dose of LPS (10 mg/kg). Results: P110 restored the pro-inflammatory cytokine response to LPS or CLP in endotoxin-tolerant mice; it improved extracellular mitochondrial membrane potential in plasma cells without affecting their number. [1] Methods: Rats underwent transient middle cerebral artery occlusion (tMCAO) surgery. After 2 h of ischemia, PKH26-labeled EXO-P110 was administered via the tail vein, with treatment lasting 24 hours. Results: P110 significantly attenuated cerebral ischemia-reperfusion injury in male rats with transient middle cerebral artery occlusion, reduced infarct size, and improved neurological function.[3]

Chemical Properties

Molecular Weight	2411.80
Formula	C₁₀₀H₁₇₉N₄₅O₂₅
Cas No.	1411976-18-5
Smiles	C([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CC(C)C)=O)CC(C)C)(=O)N1[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CO)=O)=O)CCCNC(=N)N)=O)CCC1
Relative Density.	no data available
Sequence	Asp-Leu-Leu-Pro-Arg-Gly-Ser
Sequence Short	DLLPRGS

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: 40.00 mg/mL (16.59 mM), Sonication is recommended. H2O: 1.00 mg/mL (0.41 mM), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

P110