(S,R,S)-AHPC-C5-COOH

Name: (S,R,S)-AHPC-C5-COOH
Brand: TargetMol
SKU: T18667
Rating: 4.5 (1 reviews)

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Catalog No. T18667Cas No. 2267282-19-7

Alias VH032-C5-COOH

(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized conjugate for E3 ligase ligand-linker applications, combining the VH032 VHL-based ligand with a linker for PROTAC development. VH-032 is a selective and potent VHL/HIF-1α interaction inhibitor with a dissociation constant (Kd) of 185 nM, offering potential in anemia and ischemic diseases research[1].

(S,R,S)-AHPC-C5-COOH

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Catalog No. T18667Alias VH032-C5-COOHCas No. 2267282-19-7

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Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized conjugate for E3 ligase ligand-linker applications, combining the VH032 VHL-based ligand with a linker for PROTAC development. VH-032 is a selective and potent VHL/HIF-1α interaction inhibitor with a dissociation constant (Kd) of 185 nM, offering potential in anemia and ischemic diseases research[1].
In vitro	PROTACs are bifunctional molecules consisting of two ligands linked together; one binds to an E3 ubiquitin ligase, and the other targets a specific protein. Through the utilization of the cell's ubiquitin-proteasome system, PROTACs achieve the selective degradation of target proteins. Notably, the von Hippel–Lindau (VHL) tumor suppressor protein functions as the substrate-binding component of the VHL E3 ubiquitin ligase, targeting the hydroxylated α subunit of hypoxia-inducible factors (HIFs) for ubiquitination and subsequent proteasomal degradation.
Synonyms	VH032-C5-COOH

Chemical Properties

Molecular Weight	558.73
Formula	C₂₉H₄₂N₄O₅S
Cas No.	2267282-19-7
Smiles	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NCCCCCCC(O)=O)C(C)(C)C)cc1
Relative Density.	1.218 g/cm3 (Predicted)

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Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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