BACE2 Protein, Human, Recombinant (His)

Name: BACE2 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-07036
Rating: 4.5 (1 reviews)

(Synonyms: UNQ418/PRO852, DRAP, CEAP1, CDA13, BAE2, ASP21, ASP1, ALP56, AEPLC) Copy Product Info

Synonyms: UNQ418/PRO852, DRAP, CEAP1, CDA13, BAE2, ASP21, ASP1, ALP56, AEPLC

Catalog No. TMPY-07036 Copy Product Info

BACE2 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9Y5Z0-1.

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Pack Size	Price	USA Stock	Global Stock
10 µg	$126	7-10 days	7-10 days
20 µg	$198	7-10 days	7-10 days
50 µg	$397	7-10 days	7-10 days
100 µg	$796	7-10 days	7-10 days
200 µg	$1,200	7-10 days	7-10 days
500 µg	$2,590	7-10 days	7-10 days
1 mg	$5,280	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its ability to cleave a fluorogenic peptide substrate McaKPLGLDpaARNH2，The specific activity is >70 pmol/min/μg.
Description	BACE2 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is Q9Y5Z0-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	Q9Y5Z0-1
Construction	A DNA sequence encoding the Human BACE2 (Q9Y5Z0-1) (Q9Y5Z0-1) was expressed with a polyhistidine tag at the C-terminus.
Protein Purity	≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Synonyms	UNQ418/PRO852, DRAP, CEAP1, CDA13, BAE2, ASP21, ASP1, ALP56, AEPLC
Research Background	BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.

Chemical Properties

Molecular Weight

49.39 kDa (predicted); 51.4 kDa (reducing contition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.