Shopping Cart

Your shopping cart is currently empty

DS12881479

Name: DS12881479
Brand: TargetMol
SKU: T60681
Price: 101 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T60681Cas No. 2373065-59-7

DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].

DS12881479

Copy Product Info

😃Good

Purity: 99.85%

Catalog No. T60681Cas No. 2373065-59-7

DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$101	In Stock	In Stock
5 mg	$257	In Stock	In Stock
10 mg	$387	In Stock	In Stock
25 mg	$696	In Stock	In Stock
50 mg	$936	In Stock	In Stock
100 mg	$1,230	-	In Stock
200 mg	$1,680	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

DS12881479 AI Summary

DS12881479 exhibits significant bioactivity as an inhibitor of FLT3 and DYRK1 enzymes at a concentration of 5 µM, showing more than 50% inhibition compared to the control. Additionally, it acts as an inhibitor of the inactive form of MNK1 with an IC50 value of 21.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

DS12881479 can be used in cancer research which is a potent and selective inhibitor of Mnk1(IC 50 =21 nM) [1].

Chemical Properties

Molecular Weight	301.41
Formula	C₁₆H₁₉N₃OS
Cas No.	2373065-59-7
Smiles	CN1CCC(CC1)C(=O)Nc1ncc(s1)-c1ccccc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (746.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.59 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3177 mL	16.5887 mL	33.1774 mL	165.8870 mL
5 mM	0.6635 mL	3.3177 mL	6.6355 mL	33.1774 mL
10 mM	0.3318 mL	1.6589 mL	3.3177 mL	16.5887 mL
20 mM	0.1659 mL	0.8294 mL	1.6589 mL	8.2943 mL
50 mM	0.0664 mL	0.3318 mL	0.6635 mL	3.3177 mL
100 mM	0.0332 mL	0.1659 mL	0.3318 mL	1.6589 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc