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Uliledlimab
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Catalog No. T76730Cas No. 2378407-27-1
Alias TJ-004309, TJ004309
Uliledlimab is a humanized monoclonal antibody with potent inhibitory activity against CD73, the ecto-5'-nucleotidase enzyme that catalyzes the conversion of extracellular AMP to adenosine. Uliledlimab reduces extracellular adenosine production, thereby modulating immunosuppressive pathways. Uliledlimab holds significant potential for use in immuno-oncology and cancer research.
Uliledlimab
Uliledlimab
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Purity: 95%
Catalog No. T76730Alias TJ-004309, TJ004309Cas No. 2378407-27-1
Uliledlimab is a humanized monoclonal antibody with potent inhibitory activity against CD73, the ecto-5'-nucleotidase enzyme that catalyzes the conversion of extracellular AMP to adenosine. Uliledlimab reduces extracellular adenosine production, thereby modulating immunosuppressive pathways. Uliledlimab holds significant potential for use in immuno-oncology and cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $339 | - | In Stock | |
| 5 mg | $730 | - | In Stock | |
| 10 mg | $1,160 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
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Purity:95.5% (SDS-PAGE); 95.1% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Uliledlimab is a humanized monoclonal antibody with potent inhibitory activity against CD73, the ecto-5'-nucleotidase enzyme that catalyzes the conversion of extracellular AMP to adenosine. Uliledlimab reduces extracellular adenosine production, thereby modulating immunosuppressive pathways. Uliledlimab holds significant potential for use in immuno-oncology and cancer research. |
| In vitro | Uliledlimab completely inhibits the enzymatic activity of CD73 by binding to the C-terminal domain of the CD73 protein broussonetia papyrifera. By blocking adenosine production, Uliledlimab alleviates immune cell suppression, enhances the activity of CD8+ T cells and macrophages, and ultimately strengthens the anti-tumor immune response [1]. |
| In vivo | Uliledlimab, when used alone or in combination with the PD-L1 inhibitor Atezolizumab, can effectively inhibit the growth of solid tumors [1]. |
| Synonyms | TJ-004309, TJ004309 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | NT5E/CD73 |
| Molecular Weight | 145.02 kDa |
| Cas No. | 2378407-27-1 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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