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ML-291 (Synonyms: ML291)

Name: ML-291
Brand: TargetMol
SKU: T22104
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T22104 Copy Product Info

Purity: 99.79%

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ML-291 is a potent inducer of the Unfolded Protein Response (UPR). It triggers apoptosis via the PERK/eIF2α/CHOP arm, used for solid tumor and leukemia research.

ML-291

Copy Product Info

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Catalog No. T22104

Synonyms ML291

ML-291 is a potent inducer of the Unfolded Protein Response (UPR). It triggers apoptosis via the PERK/eIF2α/CHOP arm, used for solid tumor and leukemia research.

Cas No. 1523437-16-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$32	-	In Stock
5 mg	$73	-	In Stock
10 mg	$123	-	In Stock
25 mg	$229	-	In Stock
50 mg	$339	-	In Stock
1 mL x 10 mM (in DMSO)	$80	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.79%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	ML-291 is a potent inducer of the Unfolded Protein Response (UPR). It triggers apoptosis via the PERK/eIF2α/CHOP arm, used for solid tumor and leukemia research.
In vitro	ML-291 selectively activates the PERK/eIF2α/CHOP pathway (EC50 = 762 nM), inducing ER stress apoptosis and cytotoxicity in various cancer cells [1].
Synonyms	ML291

Chemical Properties

Molecular Weight	413.83
Formula	C₁₆H₁₆ClN₃O₆S
Cas No.	1523437-16-2
Smiles	O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(S(=O)(N3CCC(CC3)Cl)=O)C=C2
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (96.66 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4165 mL	12.0823 mL	24.1645 mL	120.8226 mL
5 mM	0.4833 mL	2.4165 mL	4.8329 mL	24.1645 mL
10 mM	0.2416 mL	1.2082 mL	2.4165 mL	12.0823 mL
20 mM	0.1208 mL	0.6041 mL	1.2082 mL	6.0411 mL
50 mM	0.0483 mL	0.2416 mL	0.4833 mL	2.4165 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc