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LY3143921 hydrate

Name: LY3143921 hydrate
Brand: TargetMol
SKU: T9064
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9064Cas No. 1627696-53-0

LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].

LY3143921 hydrate

🥰Excellent

Purity: 98.43%

Catalog No. T9064Cas No. 1627696-53-0

LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].

Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$98	In Stock
10 mg	$143	In Stock
25 mg	$241	In Stock
50 mg	$365	In Stock
100 mg	$559	In Stock

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Batch Information

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Purity:98.43%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	LY3143921 ((S)-Example 2) hydrate is an orally active CDC7 kinase inhibitor with broad in vitro anticancer activity [1].
Targets&IC50	Cdc7:3.3 nM, pMCM2:290 nM

Chemical Properties

Molecular Weight	327.31
Formula	C₁₆H₁₄FN₅O₂
Cas No.	1627696-53-0
Smiles	C[C@]1(C2=C(C=C(C=C2)C3=CNN=C3)C(=O)N1)C4=NC=NC=C4F.O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (198.59 mM), Sonication is recommended.

Ethanol: 32 mg/mL (97.77 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0552 mL	15.2760 mL	30.5521 mL	152.7604 mL
5 mM	0.6110 mL	3.0552 mL	6.1104 mL	30.5521 mL
10 mM	0.3055 mL	1.5276 mL	3.0552 mL	15.2760 mL
20 mM	0.1528 mL	0.7638 mL	1.5276 mL	7.6380 mL
50 mM	0.0611 mL	0.3055 mL	0.6110 mL	3.0552 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0306 mL	0.1528 mL	0.3055 mL	1.5276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc