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N-Nornuciferine

Name: N-Nornuciferine
Brand: TargetMol
SKU: TQ0296
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0296Cas No. 4846-19-9

N-Nornuciferine is an aporphine alkaloid derived from lotus leaf that strongly inhibits CYP2D6 with an IC50 of 3.76 μM and Ki of 2.34 μM, and pharmacokinetic studies show rapid absorption into blood with mean Cmax values of 1.71 μg/mL at 0.9 h and 0.57 μg/mL at 1.65 h after administration. Following intravenous dosing at 10 mg/kg, N-Nornuciferine exhibits a wide volume of distribution of 9.48–15.17 L/kg and slow elimination half-lives of 2.09–3.84 h. the oral bioavailability of N-Nornuciferine is estimated at 58.13–79.91%. At 20 mg/kg i.v. dosing, N-Nornuciferine also rapidly crosses the blood–brain barrier, achieving unbound Cmax values of 0.32 μg/mL and 0.16 μg/mL at approximately 0.89–1.22 h.

N-Nornuciferine

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Purity: 99.63%

Catalog No. TQ0296Cas No. 4846-19-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	-	In Stock
5 mg	$172	-	In Stock
10 mg	$297	-	In Stock
25 mg	$492	-	In Stock
50 mg	$717	-	In Stock
100 mg	$988	-	In Stock
1 mL x 10 mM (in DMSO)	$188	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.63%

Appearance:Solid

Color:Brown

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	N-Nornuciferine is an aporphine alkaloid derived from lotus leaf that strongly inhibits CYP2D6 with an IC50 of 3.76 μM and Ki of 2.34 μM, and pharmacokinetic studies show rapid absorption into blood with mean Cmax values of 1.71 μg/mL at 0.9 h and 0.57 μg/mL at 1.65 h after administration. Following intravenous dosing at 10 mg/kg, N-Nornuciferine exhibits a wide volume of distribution of 9.48–15.17 L/kg and slow elimination half-lives of 2.09–3.84 h. the oral bioavailability of N-Nornuciferine is estimated at 58.13–79.91%. At 20 mg/kg i.v. dosing, N-Nornuciferine also rapidly crosses the blood–brain barrier, achieving unbound Cmax values of 0.32 μg/mL and 0.16 μg/mL at approximately 0.89–1.22 h.
Targets&IC50	CYP2D6:3.76 μM, CYP2D6:2.34 μM (Ki)
In vitro	N-Nornuciferine exhibits potent inhibitory effects on CYP2D6 enzyme activity, while demonstrating only weak or no inhibitory effects on the other four cytochrome P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). Furthermore, N-Nornuciferine competitively inhibits the CYP2D6-catalyzed O-demethylation reaction of dextromethorphan, with a Ki value of 2.34 μM [1].

Chemical Properties

Molecular Weight	281.35
Formula	C₁₈H₁₉NO₂
Cas No.	4846-19-9
Smiles	O(C)C1=C2C=3[C@@](CC=4C2=CC=CC4)(NCCC3C=C1OC)[H]
Relative Density.	1.163 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (284.34 mM), Sonication is recommeded.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5543 mL	17.7715 mL	35.5429 mL	177.7146 mL
5 mM	0.7109 mL	3.5543 mL	7.1086 mL	35.5429 mL
10 mM	0.3554 mL	1.7771 mL	3.5543 mL	17.7715 mL
20 mM	0.1777 mL	0.8886 mL	1.7771 mL	8.8857 mL
50 mM	0.0711 mL	0.3554 mL	0.7109 mL	3.5543 mL
100 mM	0.0355 mL	0.1777 mL	0.3554 mL	1.7771 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc