This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
Tubulin polymerization-IN-2
Catalog No. T60802 CAS
2873399-22-3
Tubulin Polymerization-IN-2 is a powerful anticancer agent that targets β-tubulin, exhibiting an IC 50 of 0.92 μM. It demonstrates promising efficacy against a range of cancer cell lines including leukemia, non-small cell lung, renal, prostate, and breast cancers [1].
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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.
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Biological Description
Chemical Properties
Storage
& Solubility Information
Description
Tubulin Polymerization-IN-2 is a powerful anticancer agent that targets β-tubulin, exhibiting an IC 50 of 0.92 μM. It demonstrates promising efficacy against a range of cancer cell lines including leukemia, non-small cell lung, renal, prostate, and breast cancers [1].
In vitro
Tubulin polymerization-IN-2 (compound 2b) exhibits potent anti-cancer properties, effectively targeting epidermal carcinoma and breast carcinoma with IC50 values of 2.3 μM (KB) and 2.2 μM (BT-549), respectively [1]. At a concentration of 0.342 μM over 24 hours, it disrupts DNA synthesis or repair mechanisms and causes an arrest in the S phase of the cell cycle in MCF-7 cells [1]. Furthermore, the same concentration prompts apoptosis by diminishing the expression of Bax, APAF-1, and caspase-3, while concurrently increasing BCL-2 mRNA levels [1]. It also demonstrates significant inhibitory effects on β-tubulin polymerization at concentrations ranging from 0.01 to 10 μM over one hour, evidenced by a K_i value of 0.09 μM [1].
Molecular Weight
314.29
Formula
C17H12F2N2O2
CAS No.
2873399-22-3
Storage
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dose Conversion
You can also refer to dose conversion for different animals.
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Method for preparing DMSO master liquid: mg
drug pre-dissolved in μL DMSO (Master liquid concentration
mg/mL),
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL PEG300, mix and clarify, next add μL
Tween 80,mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation:Take μL
DMSO master liquid, next add μL Corn oil,mix and clarify.
Note:
Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.