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K-Ras ligand-Linker Conjugate 3

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Catalog No. T18056Cas No. 2378261-87-9

K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].

K-Ras ligand-Linker Conjugate 3

K-Ras ligand-Linker Conjugate 3

😃Good
Catalog No. T18056Cas No. 2378261-87-9
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Bioactivity
Description
K-Ras ligand-Linker Conjugate 3 (Compound 001371) is a chemical compound comprising a ligand for the K-Ras recruiting moiety and a PROTAC linker, responsible for recruiting E3 ligases (e.g., VHL, CRBN, MDM2, and IAP). This compound is essential for synthesizing PROTAC K-Ras Degrader-1, a potent degrader with a degradation efficacy of ≥70% in SW1573 cells[1].
In vitro
PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase and the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Chemical Properties
Molecular Weight944.15
FormulaC49H65N7O10S
Cas No.2378261-87-9
SmilesO(C[C@@H]1C[C@@H](OCCOCCOCCOCCOS(=O)(=O)C2=CC=C(C)C=C2)CN1C)C3=NC(=C4C(CN(CC4)C=5C6=C(C=CC5)C=CC=C6)=N3)N7C[C@H](CC#N)N(C(OC(C)(C)C)=O)CC7
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

K-Ras ligand-Linker Conjugate 3KRas ligandLinker Conjugate 3K Ras ligand Linker Conjugate 3
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