keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and emission spectra at 392/427 nm, respectively. It serves to label serotonergic neurons within mouse brain tissue via SERT-dependent accumulation [1].
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Description | FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and emission spectra at 392/427 nm, respectively. It serves to label serotonergic neurons within mouse brain tissue via SERT-dependent accumulation [1]. |
In vivo | FFN246, at concentrations ranging from 2.5 to 20 μM and a 30-minute incubation, can be employed for direct detection of serotonin transporter (SERT) activity and SERT inhibitors in 96-well plate cell culture assays. It can also specifically label serotonergic neurons in the dorsal raphe nucleus within acute mouse brain slices [1]. Additionally, FFN246 at 20 μM for 30 minutes effectively traces serotonin uptake and packaging in the somata of serotonergic neurons [1]. |
Molecular Weight | 256.27 |
Formula | C15H13FN2O |
CAS No. | 2210244-83-8 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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FFN246 2210244-83-8 GPCR/G Protein Neuroscience 5-HT Receptor inhibitor inhibit