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FFN246

Name: FFN246
Brand: TargetMol
SKU: T78684
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78684Cas No. 2210244-83-8

Alias FFN-246, FFN 246

FFN246 is a fluorescent dual-substrate probe for serotonin transporter and vesicular monoamine transporter 2 with defined excitation and emission spectra of 392/427 nm, FFN246 enables selective labeling of serotonergic neurons in mouse brain tissue through SERT-dependent uptake and facilitating visualization of monoaminergic neurotransmission dynamics.

FFN246

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Catalog No. T78684Alias FFN-246, FFN 246Cas No. 2210244-83-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$40	-	In Stock
5 mg	$92	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	FFN246 is a fluorescent dual-substrate probe for serotonin transporter and vesicular monoamine transporter 2 with defined excitation and emission spectra of 392/427 nm, FFN246 enables selective labeling of serotonergic neurons in mouse brain tissue through SERT-dependent uptake and facilitating visualization of monoaminergic neurotransmission dynamics.
In vivo	In high-throughput screening applications utilizing 96-well cell culture formats, FFN246 functioned as a versatile fluorescent probe for the assessment of Serotonin Transporter (SERT) activity. Over a 30-minute incubation period with concentrations ranging from 2.5 to 20 uM, the compound enabled the direct monitoring of transporter functionality and the evaluation of potential inhibitors [1]. Extending its utility to ex vivo models, specifically acute mouse brain slices, FFN246 (20 uM) selectively labeled serotonergic neurons within the dorsal raphe nucleus. This application allowed for the visualization of physiological serotonin uptake dynamics and vesicle packaging processes within the neuronal somas [1].
Synonyms	FFN-246, FFN 246

Chemical Properties

Molecular Weight	256.27
Formula	C₁₅H₁₃FN₂O
Cas No.	2210244-83-8
Smiles	O=C1C2=CC(=CC=C2NC=3C=CC=C(F)C13)CCN

Storage & Solubility Information

Storage

keep away from direct sunlight | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 13 mg/mL (50.73 mM), when pH is adjusted to 1 with 1 M HCl. Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9021 mL	19.5107 mL	39.0213 mL	195.1067 mL
5 mM	0.7804 mL	3.9021 mL	7.8043 mL	39.0213 mL
10 mM	0.3902 mL	1.9511 mL	3.9021 mL	19.5107 mL
20 mM	0.1951 mL	0.9755 mL	1.9511 mL	9.7553 mL
50 mM	0.0780 mL	0.3902 mL	0.7804 mL	3.9021 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

5HTReceptor5HT Receptor