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FFN246
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Catalog No. T78684Cas No. 2210244-83-8
Alias FFN-246, FFN 246
FFN246 is a fluorescent dual-substrate probe for serotonin transporter and vesicular monoamine transporter 2 with defined excitation and emission spectra of 392/427 nm, FFN246 enables selective labeling of serotonergic neurons in mouse brain tissue through SERT-dependent uptake and facilitating visualization of monoaminergic neurotransmission dynamics.
FFN246
😃Good
Catalog No. T78684Alias FFN-246, FFN 246Cas No. 2210244-83-8
FFN246 is a fluorescent dual-substrate probe for serotonin transporter and vesicular monoamine transporter 2 with defined excitation and emission spectra of 392/427 nm, FFN246 enables selective labeling of serotonergic neurons in mouse brain tissue through SERT-dependent uptake and facilitating visualization of monoaminergic neurotransmission dynamics.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $40 | - | In Stock | |
| 5 mg | $92 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | FFN246 is a fluorescent dual-substrate probe for serotonin transporter and vesicular monoamine transporter 2 with defined excitation and emission spectra of 392/427 nm, FFN246 enables selective labeling of serotonergic neurons in mouse brain tissue through SERT-dependent uptake and facilitating visualization of monoaminergic neurotransmission dynamics. |
| In vivo | FFN246, at concentrations ranging from 2.5 to 20 μM and a 30-minute incubation, can be employed for direct detection of serotonin transporter (SERT) activity and SERT inhibitors in 96-well plate cell culture assays. It can also specifically label serotonergic neurons in the dorsal raphe nucleus within acute mouse brain slices [1]. Additionally, FFN246 at 20 μM for 30 minutes effectively traces serotonin uptake and packaging in the somata of serotonergic neurons [1]. |
| Synonyms | FFN-246, FFN 246 |
| Molecular Weight | 256.27 |
| Formula | C15H13FN2O |
| Cas No. | 2210244-83-8 |
| Smiles | O=C1C2=CC(=CC=C2NC=3C=CC=C(F)C13)CCN |
| Color | Yellow |
| Appearance | Solid |
| Storage | keep away from direct sunlight | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 13 mg/mL (50.73 mM), when pH is adjusted to 1 with 1 M HCl. Sonication and heating are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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