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IRAK4-IN-17

Catalog No. T61767 CAS 2183503-33-3

IRAK4-IN-17 (Compound 5) is a highly potent inhibitor of IRAK4, exhibiting an impressive IC50 value of 1.3 nM [1]. This compound is particularly valuable for research focused on large B-cell lymphoma (DLBCL) [1].

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IRAK4-IN-17, CAS 2183503-33-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

IRAK4-IN-17, at concentrations ranging from 0.7 to 40.1 μM over 72 hours, selectively inhibits OCI-LY10 and TMD8 cell lines harboring the MYD88 L265P mutation. At a lower concentration range of 0.3 to 10 μM for 2 hours, it targets the IRAK4 signaling pathway, reducing the viability of DLBCL (Diffuse Large B-Cell Lymphoma) cells. The compound exhibits varying cytotoxic effects, with IC50 values of 0.7 μM and 1.2 μM against OCI-LY10 and TMD8 cells, respectively, indicating its potent suppression capability, whereas it displays diminished effectiveness on Ramos and HT cell lines with wild-type MYD88, evidenced by IC50 values of 11.4 μM and 40.1 μM. Western Blot analysis further supports these findings by showing inhibition of IRAK4 phosphorylation and the downstream molecules, IKKβ and NF-κB transcription factor (p65), in OCI-LY10 and TMD8 cells, confirming the compound's targeted mechanistic action.

Molecular Weight	390.39
Formula	C17H20F2N8O
CAS No.	2183503-33-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IRAK4-IN-17 2183503-33-3 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.