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Irilone
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Catalog No. TN6524Cas No. 41653-81-0
Alias Irolone, 5,4'-Dihydroxy-6,7-methylenedioxyisoflavone
Irilone is a flavonoid with α-amylase inhibitory activity and highly selective inhibition of CYP3A4. In addition, Irilone enhances progesterone receptor (PR) signaling via estrogen receptor (ER) and glucocorticoid receptor (GR) when combined with progesterone.Irilone has potential anti-inflammatory activity and inhibits nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 in mouse macrophages.
Irilone
😃Good
Catalog No. TN6524Alias Irolone, 5,4'-Dihydroxy-6,7-methylenedioxyisoflavoneCas No. 41653-81-0
Irilone is a flavonoid with α-amylase inhibitory activity and highly selective inhibition of CYP3A4. In addition, Irilone enhances progesterone receptor (PR) signaling via estrogen receptor (ER) and glucocorticoid receptor (GR) when combined with progesterone.Irilone has potential anti-inflammatory activity and inhibits nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 in mouse macrophages.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $678 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Irilone is a flavonoid with α-amylase inhibitory activity and highly selective inhibition of CYP3A4. In addition, Irilone enhances progesterone receptor (PR) signaling via estrogen receptor (ER) and glucocorticoid receptor (GR) when combined with progesterone.Irilone has potential anti-inflammatory activity and inhibits nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 in mouse macrophages. |
| In vitro | Methods:In the current study, we used a progesterone response element (pre)-acidase (LUC) reporter gene assay to identify four phytochemicals present in standardized red clover (Trifolium Pratense) extracts. Results: Irilone (1) potentiated the effects of progesterone in endometrial and ovarian cancer cell lines. In these cancers, progesterone action is usually associated with positive outcomes. Thus, the potentiation of 1 may provide novel strategies to enhance progesterone signaling as a means to alleviate diseases such as leiomyosarcoma and endometriosis. [1] |
| Alias | Irolone, 5,4'-Dihydroxy-6,7-methylenedioxyisoflavone |
| Molecular Weight | 298.25 |
| Formula | C16H10O6 |
| Cas No. | 41653-81-0 |
| Smiles | O=C1C(=COC=2C=C3OCOC3=C(O)C12)C=4C=CC(O)=CC4 |
| Relative Density. | 1.592 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (6.71 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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