Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Irilone (Synonyms: Irolone, 5,4'-Dihydroxy-6,7-methylenedioxyisoflavone)

Name: Irilone
Brand: TargetMol
SKU: TN6524
Rating: 4.5 (1 reviews)

Catalog No. TN6524 Copy Product Info

🥰Excellent

Irilone is a flavonoid with α-amylase inhibitory activity and highly selective inhibition of CYP3A4. In addition, Irilone enhances progesterone receptor (PR) signaling via estrogen receptor (ER) and glucocorticoid receptor (GR) when combined with progesterone.Irilone has potential anti-inflammatory activity and inhibits nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 in mouse macrophages.

Irilone

Copy Product Info

🥰Excellent

Catalog No. TN6524

Synonyms Irolone, 5,4'-Dihydroxy-6,7-methylenedioxyisoflavone

Cas No. 41653-81-0

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$678	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Irilone is a flavonoid with α-amylase inhibitory activity and highly selective inhibition of CYP3A4. In addition, Irilone enhances progesterone receptor (PR) signaling via estrogen receptor (ER) and glucocorticoid receptor (GR) when combined with progesterone.Irilone has potential anti-inflammatory activity and inhibits nitric oxide (NO) production by lipopolysaccharide (LPS)-induced RAW264.7 in mouse macrophages.
In vitro	Methods:In the current study, we used a progesterone response element (pre)-acidase (LUC) reporter gene assay to identify four phytochemicals present in standardized red clover (Trifolium Pratense) extracts. Results: Irilone (1) potentiated the effects of progesterone in endometrial and ovarian cancer cell lines. In these cancers, progesterone action is usually associated with positive outcomes. Thus, the potentiation of 1 may provide novel strategies to enhance progesterone signaling as a means to alleviate diseases such as leiomyosarcoma and endometriosis. [1]
Synonyms	Irolone, 5,4'-Dihydroxy-6,7-methylenedioxyisoflavone

Chemical Properties

Molecular Weight	298.25
Formula	C₁₆H₁₀O₆
Cas No.	41653-81-0
Smiles	O=C1C(=COC=2C=C3OCOC3=C(O)C12)C=4C=CC(O)=CC4
Relative Density.	1.592 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2 mg/mL (6.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3529 mL	16.7645 mL	33.5289 mL	167.6446 mL
5 mM	0.6706 mL	3.3529 mL	6.7058 mL	33.5289 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc