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MC-VC-PAB-NH2 TFA

Name: MC-VC-PAB-NH2 TFA
Brand: TargetMol
SKU: T77829
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77829Cas No. 1616727-21-9

MC-VC-PAB-NH2 TFA is a degradable ADC linker for synthesizing antibody-drug conjugates (ADCs).

MC-VC-PAB-NH2 TFA

😃Good

Purity: 99.93%

Catalog No. T77829Cas No. 1616727-21-9

MC-VC-PAB-NH2 TFA is a degradable ADC linker for synthesizing antibody-drug conjugates (ADCs).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$81	-	In Stock
5 mg	$208	-	In Stock
10 mg	$338	-	In Stock
25 mg	$565	-	In Stock
50 mg	$789	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Questions

Batch Information

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Purity:99.93%

Resource Download

COA MS HPLC

Product Introduction

Bioactivity

Description

MC-VC-PAB-NH2 TFA is a degradable ADC linker for synthesizing antibody-drug conjugates (ADCs).

Chemical Properties

Molecular Weight	772.77
Formula	C₃₃H₄₇F₃N₈O₁₀
Cas No.	1616727-21-9
Smiles	C(C(O)=O)(F)(F)F.[C@H](C(NC1=CC=C(COC(NCCN)=O)C=C1)=O)(NC([C@@H](NC(CCCCCN2C(=O)C=CC2=O)=O)C(C)C)=O)CCCNC(N)=O
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (103.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2940 mL	6.4702 mL	12.9405 mL	64.7023 mL
5 mM	0.2588 mL	1.2940 mL	2.5881 mL	12.9405 mL
10 mM	0.1294 mL	0.6470 mL	1.2940 mL	6.4702 mL
20 mM	0.0647 mL	0.3235 mL	0.6470 mL	3.2351 mL
50 mM	0.0259 mL	0.1294 mL	0.2588 mL	1.2940 mL
100 mM	0.0129 mL	0.0647 mL	0.1294 mL	0.6470 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc