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Kuwanon E

Name: Kuwanon E
Brand: TargetMol
SKU: TN1848
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TN1848Cas No. 68401-05-8

Kuwanon E, a flavonoid obtained from Morus alba, has potential anti-inflammatory activity, inhibits TNF-α and IL-1β secretion, and suppresses NF-κB nuclear translocation in LPS-stimulated macrophages.

Kuwanon E

🥰Excellent

Purity: 98.37%

Catalog No. TN1848Cas No. 68401-05-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$198	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.37%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Kuwanon E, a flavonoid obtained from Morus alba, has potential anti-inflammatory activity, inhibits TNF-α and IL-1β secretion, and suppresses NF-κB nuclear translocation in LPS-stimulated macrophages.
In vitro	METHODS: THP-1 cells were exposed to different concentrations of Kuwanon E (1, 2.5, 5, 10, 20, and 50 μM) for 24 hours, stained for activity, and counted using a hemocytometer. RESULTS: The LD50 value of Kuwanon E was greater than 50 μM and inhibited the proliferation of THP-1 cells. [1]

Chemical Properties

Molecular Weight	424.49
Formula	C₂₅H₂₈O₆
Cas No.	68401-05-8
Smiles	CC(C)=CCC\C(C)=C\Cc1cc(C2CC(=O)c3c(O)cc(O)cc3O2)c(O)cc1O
Relative Density.	1.273 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (70.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3558 mL	11.7788 mL	23.5577 mL	117.7884 mL
5 mM	0.4712 mL	2.3558 mL	4.7115 mL	23.5577 mL
10 mM	0.2356 mL	1.1779 mL	2.3558 mL	11.7788 mL
20 mM	0.1178 mL	0.5889 mL	1.1779 mL	5.8894 mL
50 mM	0.0471 mL	0.2356 mL	0.4712 mL	2.3558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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