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PMVK Protein, Human, Recombinant (His)
(Synonyms: PMKASE, PMKA, PMK, phosphomevalonate kinase, HUMPMKI) Copy Product InfoSynonyms: PMKASE, PMKA, PMK, phosphomevalonate kinase, HUMPMKI
Catalog No. TMPY-04767 Copy Product Info
PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $76 | 7-10 days | 7-10 days | |
| 10 μg | $118 | 7-10 days | 7-10 days | |
| 20 μg | $197 | 7-10 days | 7-10 days | |
| 50 μg | $458 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Kinase activity untested |
| Description | PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. |
| Species | Human |
| Expression System | E. coli |
| Tag | N-His |
| Accession Number | Q15126 |
| Construction | A DNA sequence encoding the mature form of human PMVK(Q15126) (Met1-Leu192) was expressed with a polyhistidine tag at the N-terminus. Predicted N terminal: His |
| Protein Purity | > 90 % as determined by SDS-PAGE |
| Endotoxin | Please contact us for more information. |
| Formulation | Supplied as sterile 50 mM MOPS, 150 mM KCl, 1 mM DTT, pH 7.0. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Stability & Storage | It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | Proteins are shipped with blue ice. |
| Synonyms | PMKASE, PMKA, PMK, phosphomevalonate kinase, HUMPMKI |
| Research Background |
| Molecular Weight | 23.8 kDa (predicted); 24 kDa (reducing conditions) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: PMVK Protein, Human, Recombinant (His) chemical structure | PMVK Protein, Human, Recombinant (His) molecular weight
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