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Mal-PEG8-Val-Ala-PAB-Exatecan

Name: Mal-PEG8-Val-Ala-PAB-Exatecan
Brand: TargetMol
SKU: T77855
Rating: 4.5 (1 reviews)

Catalog No. T77855 Copy Product Info

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Mal-PEG8-Val-Ala-PAB-Exatecan is an ADC linker-payload featuring a cathepsin B-cleavable Val-Ala linker and Exatecan. It is used for Nectin-4 targeted ADC development.

Mal-PEG8-Val-Ala-PAB-Exatecan

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Catalog No. T77855

Mal-PEG8-Val-Ala-PAB-Exatecan is an ADC linker-payload featuring a cathepsin B-cleavable Val-Ala linker and Exatecan. It is used for Nectin-4 targeted ADC development.

Cas No. 2679821-39-5

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$550	8-10 weeks	8-10 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Mal-PEG8-Val-Ala-PAB-Exatecan is an ADC linker-payload featuring a cathepsin B-cleavable Val-Ala linker and Exatecan. It is used for Nectin-4 targeted ADC development.
Targets&IC50	Topoisomerase I:0.97 μM
In vivo	In KPL-4 xenograft models, conjugates with Mal-PEG8-Val-Ala-PAB-Exatecan (1-10 mg/kg) induced durable tumor regression and prolonged survival[1].

Chemical Properties

Molecular Weight	1329.42
Formula	C₆₆H₈₅FN₈O₂₀
Cas No.	2679821-39-5
Smiles	N(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(=O)C=CC2=O)=O)=O)[C@H](C)C)=O)C)=O)C=C1)=O)[C@@H]3C4=C5C(C=6N(C5)C(=O)C7=C(C6)[C@](CC)(O)C(=O)OC7)=NC=8C4=C(CC3)C(C)=C(F)C8

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (60.18 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7522 mL	3.7610 mL	7.5221 mL	37.6104 mL
5 mM	0.1504 mL	0.7522 mL	1.5044 mL	7.5221 mL
10 mM	0.0752 mL	0.3761 mL	0.7522 mL	3.7610 mL
20 mM	0.0376 mL	0.1881 mL	0.3761 mL	1.8805 mL
50 mM	0.0150 mL	0.0752 mL	0.1504 mL	0.7522 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc