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4-Hydroxyphenylglyoxylic Acid (Synonyms: UK 22486)

Name: 4-Hydroxyphenylglyoxylic Acid
Brand: TargetMol
SKU: T83767
Rating: 4.5 (1 reviews)

Catalog No. T83767 Copy Product Info

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4-Hydroxyphenylglyoxylic acid, an active metabolite of the prodrug oxfenicine, functions as an inhibitor of carnitine palmitoyltransferase 1 (CPT1). It effectively inhibits CPT1 in isolated rat liver mitochondria at concentrations of 200 to 1,000 µM and restricts oleate oxidation in isolated rat hepatocytes.

4-Hydroxyphenylglyoxylic Acid

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Catalog No. T83767

Synonyms UK 22486

Cas No. 15573-67-8

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Pack Size	Price	USA Stock	Global Stock
5 mg	$142	35 days	35 days
10 mg	$275	35 days	35 days
50 mg	$1,150	35 days	35 days
100 mg	$2,160	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	4-Hydroxyphenylglyoxylic acid, an active metabolite of the prodrug oxfenicine, functions as an inhibitor of carnitine palmitoyltransferase 1 (CPT1). It effectively inhibits CPT1 in isolated rat liver mitochondria at concentrations of 200 to 1,000 µM and restricts oleate oxidation in isolated rat hepatocytes.
Synonyms	UK 22486

Chemical Properties

Molecular Weight	166.13
Formula	C₈H₆O₄
Cas No.	15573-67-8
Smiles	OC(=O)C(=O)c1ccc(O)cc1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (120.39 mM), Sonication is recommended.

DMF: 20 mg/mL (120.39 mM), Sonication is recommended.

PBS pH 7.2: 10 mg/mL (60.19 mM), Sonication is recommended.

Ethanol: 10 mg/mL (60.19 mM), Sonication is recommended.

Solution Preparation Table

PBS pH 7.2/Ethanol/DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	6.0194 mL	30.0969 mL	60.1938 mL	300.9691 mL
5 mM	1.2039 mL	6.0194 mL	12.0388 mL	60.1938 mL
10 mM	0.6019 mL	3.0097 mL	6.0194 mL	30.0969 mL
20 mM	0.3010 mL	1.5048 mL	3.0097 mL	15.0485 mL
50 mM	0.1204 mL	0.6019 mL	1.2039 mL	6.0194 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc