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Itolizumab

Catalog No. T76781 CAS 1116433-11-4

Synonyms: EQ-001

Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6. Itolizumab slows T cell proliferation and inhibits the production of pro-inflammatory cytokines. Itolizumab can be used to study conditions as diverse as psoriasis, rheumatoid arthritis (RA) and COVID-19 disease.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Itolizumab

Itolizumab, CAS 1116433-11-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 372.00
5 mg	In stock	$ 972.00
10 mg	In stock	$ 1,530.00
25 mg	In stock	$ 2,280.00
50 mg	In stock	$ 2,970.00
100 mg	In stock	$ 4,180.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Itolizumab (Anti-Human CD6 Recombinant Antibody) is a recombinant anti-CD6 monoclonal antibody that humanizes the extracellular SRCR distal domain 1 of CD6. Itolizumab slows T cell proliferation and inhibits the production of pro-inflammatory cytokines. Itolizumab can be used to study conditions as diverse as psoriasis, rheumatoid arthritis (RA) and COVID-19 disease.
In vitro	Inhibiting T cell proliferation, Itolizumab is effective at a concentration of 100 μg/mL[1]. In PBMCs, Itolizumab (0-100 μg/mL) inhibits Treg polarization and enhances the acquisition of the Th1 phenotype[1]. During overnight culture of PBMCs, Itolizumab at 40 μg/mL reduces CD26hiCD161+ CD8+ T cells[2]. In PBMCs stimulated in Th17 polarizing conditions, Itolizumab at 40 μg/mL for 3-12 days reduces the expression of IL-17 and IFN-γ[3].
In vivo	In a humanized xenograft mouse model of Graft Vs Host Disease (GVHD), Itolizumab demonstrates therapeutic efficacy when administered intraperitoneally at doses of 60 μg or 300 μg daily[4].

Synonyms	EQ-001
Molecular Weight	N/A
CAS No.	1116433-11-4

Storage

store at low temperature

store at -80°C

References and Literature

1. Freitas RF, et al. Modulation of CD4 T cell function via CD6-targeting. EBioMedicine. 2019 Sep;47:427-435. [Content Brief] 2. Globig AM, et al. High-dimensional profiling reveals Tc17 cell enrichment in active Crohn's disease and identifies a potentially targetable signature. Nat Commun. 2022 Jun 27;13(1):3688. 3. Bughani U, et al. T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab. PLoS One. 2017 Jul 3;12(7):e0180088. 4. Cherie Tracy Ng, et al. Itolizumab As a Potential Therapeutic for the Prevention and Treatment of Graft Vs Host Disease. Blood (2019) 134 (Supplement_1): 5603.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Itolizumab 1116433-11-4 Others EQ 001 EQ-001 EQ001 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.