Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest in the S phase and G2/M phase. This agent exhibits moderate anti-inflammatory efficacy alongside a notable safety profile. Additionally, it possesses the uncommon capability of inhibiting tumor development in a mouse model, indicative of anti-cancer properties [1].
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Description | Anti-inflammatory agent 52 (compound 7c) is an orally active, selective COX-2 inhibitor with demonstrated anti-HT29 metastatic activity, causing periodic arrest in the S phase and G2/M phase. This agent exhibits moderate anti-inflammatory efficacy alongside a notable safety profile. Additionally, it possesses the uncommon capability of inhibiting tumor development in a mouse model, indicative of anti-cancer properties [1]. |
In vitro | Anti-inflammatory agent 53 (compound 7c) at a concentration of 0.25 μM over 24 hours inhibits colony formation in HT29 cells and induces cell cycle arrest at the G2/M and S phases [1]. |
In vivo | Anti-inflammatory agent 53 (compound 7c) at a dosage of 50 mg/kg, administered orally every other day for two weeks, was found to reduce tumor volume and weight in mice with Ehrlich's ascites carcinoma [1]. |
Molecular Weight | 434.51 |
Formula | C24H22N2O4S |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Anti-inflammatory agent 53 Immunology/Inflammation Neuroscience COX inhibitor inhibit