Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC3/6-IN-2 (compound 15) is a dual inhibitor targeting HDAC6 and HDAC3, exhibiting potent activity with IC50 values of 0.368 μM for HDAC6 and 0.635 μM for HDAC3. This compound demonstrates antitumor effects by inducing apoptosis in cancer cells and reducing HDAC6 and HDAC3 levels. This action is linked to the increased acetylation of H3 and α-tubulin [1].
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Description | HDAC3/6-IN-2 (compound 15) is a dual inhibitor targeting HDAC6 and HDAC3, exhibiting potent activity with IC50 values of 0.368 μM for HDAC6 and 0.635 μM for HDAC3. This compound demonstrates antitumor effects by inducing apoptosis in cancer cells and reducing HDAC6 and HDAC3 levels. This action is linked to the increased acetylation of H3 and α-tubulin [1]. |
Molecular Weight | 822.09 |
Formula | C49H67N5O6 |
CAS No. | 2417510-17-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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HDAC3/6-IN-2 2417510-17-7 inhibitor inhibit