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S65487

Name: S65487
Brand: TargetMol
SKU: T36897
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36897Cas No. 1644600-79-2

Alias VOB560, VOB 560

S65487 (VOB560) is a potent and selective inhibitor of the anti-apoptotic protein Bcl-2, displaying activity not only against the wild-type protein but also against clinically relevant BCL-2 mutations such as G101V and D103Y. S65487 demonstrates poor affinity toward other Bcl-2 family members, including MCL-1, BFL-1, and BCL-XL, which underlines its selectivity profile. S65487 induces apoptosis in cancer cells and exhibits robust anticancer activities in preclinical studies.

S65487

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Purity: 99.03%

Catalog No. T36897Alias VOB560, VOB 560Cas No. 1644600-79-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	-	In Stock
5 mg	$347	-	In Stock
10 mg	$579	-	In Stock
25 mg	$1,160	-	In Stock
1 mL x 10 mM (in DMSO)	$548	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.03%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	S65487 (VOB560) is a potent and selective inhibitor of the anti-apoptotic protein Bcl-2, displaying activity not only against the wild-type protein but also against clinically relevant BCL-2 mutations such as G101V and D103Y. S65487 demonstrates poor affinity toward other Bcl-2 family members, including MCL-1, BFL-1, and BCL-XL, which underlines its selectivity profile. S65487 induces apoptosis in cancer cells and exhibits robust anticancer activities in preclinical studies.
In vitro	S65487 effectively induces apoptosis and inhibits proliferation in a panel of hematologic cancer cell lines by binding to the BH3 hydrophobic groove of the BCL-2 protein, with a half-maximal inhibitory concentration (IC50) in the low nanomolar (nM) range. [1]
In vivo	S65487 effectively induces complete regression in BCL-2-dependent RS4;11 tumors through a single intravenous (IV) dose and demonstrates consistent, strong tumor regression in mouse and rat xenograft models of lymphoid malignancies at tolerable doses with weekly IV administrations when combined with MCL-1-specific inhibitor S64315/MIK665.[1]
Synonyms	VOB560, VOB 560

Chemical Properties

Molecular Weight	717.26
Formula	C₄₁H₄₁ClN₆O₄
Cas No.	1644600-79-2
Smiles	N(C(=O)C=1C=C(N(C)C1C)C2=C(C(=O)N3[C@H](CN4CCOCC4)CC=5C(C3)=CC=CC5)C=CC(Cl)=C2)(C=6C=C(C#N)N(C)C6C)C7=CC=C(O)C=C7

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (223.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3942 mL	6.9710 mL	13.9419 mL	69.7097 mL
5 mM	0.2788 mL	1.3942 mL	2.7884 mL	13.9419 mL
10 mM	0.1394 mL	0.6971 mL	1.3942 mL	6.9710 mL
20 mM	0.0697 mL	0.3485 mL	0.6971 mL	3.4855 mL
50 mM	0.0279 mL	0.1394 mL	0.2788 mL	1.3942 mL
100 mM	0.0139 mL	0.0697 mL	0.1394 mL	0.6971 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc