Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S65487 (VOB560) is a potent and selective Bcl-2 inhibitor. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities[1][2].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,490.00 | |
50 mg | 6-8 weeks | $ 2,480.00 | |
100 mg | 6-8 weeks | $ 3,810.00 |
Description | S65487 (VOB560) is a potent and selective Bcl-2 inhibitor. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities[1][2]. |
In vitro | S65487 binds to the BH3 hydrophobic groove of BCL-2. S65487 induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range[1]. |
In vivo | S65487 effectively induces complete regression in BCL-2-dependent RS4;11 tumors through a single intravenous (IV) dose and demonstrates consistent, strong tumor regression in mouse and rat xenograft models of lymphoid malignancies at tolerable doses with weekly IV administrations when combined with MCL-1-specific inhibitor S64315/MIK665[1]. |
Molecular Weight | 717.26 |
Formula | C41H41ClN6O4 |
CAS No. | 1644600-79-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S65487 1644600-79-2 S 65487 S-65487 inhibitor inhibit